MGI phenotypes (gene matching)
NOD.B6-(D17Mit114-D17Mit101)/Orl
| Status | Available to order |
| EMMA ID | EM:01402 |
| International strain name | NOD.B6-(D17Mit114-D17Mit101)/Orl |
| Alternative name | NOD.B6-C17(R76.22) |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Idd16.1, Ceat1 |
| Gene/Transgene symbol | Idd16.1, Ceat1 |
Information from provider
| Provider | Henri-Jean Garchon |
| Provider affiliation | ER70 CNRS et Unite 125 Inserm |
| Genetic information | NOD subcongenic strain with an interval proximal to the H2 complex from C57BL/6. The R76.22 interval is derived from R76. |
| Phenotypic information | This line and the related lines, consomic, congenic and subcongenic for chromosome 17 and fragments of this chromosome, were derived to thoroughly investigate the role of the major histocompatibility complex (MHC) and MHC-linked genes in autoimmune predisposition, notably including type I diabetes (Idd1 and Idd16) loci and chronic autoimmune thyroiditis (Ceat1) locus, on the non-obese diabetic (NOD) background. The R76.22 line is partially protected against type 1 diabetes and defines the Idd16.1 locus for type 1 diabetes. Some of the frozen embryos have been obtained thanks to a crossing between an homozygous male and a NOD wild-type females. |
| Breeding history | 20 generations of backcrosses followed by sister-brother matings. Selection of subcongenics by additional backcrosses. |
| References | None available |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |