NOD.B6-(D17Mit16-D17Mit36)/GhjCnrm

Status

Available to order

EMMA IDEM:01398
International strain nameNOD.B6-(D17Mit16-D17Mit36)/GhjCnrm
Alternative nameNOD.B6-C17(R2)
Strain typeOther
Allele/Transgene symbolIdd1C57BL/6, H2b
Gene/Transgene symbolIdd1, H2

Information from provider

ProviderHenri-Jean Garchon
Provider affiliationER70 CNRS et Unite 125 Inserm
Genetic informationNOD congenic strain with the H2 complex from C57BL/6. The R2 interval includes the Idd1 but excludes the Idd16 locus.
Phenotypic informationThis line and the related lines, consomic, congenic and subcongenic for chromosome 17 and fragments of this chromosome, were derived to thoroughly investigate the role of the major histocompatibility complex (MHC) and MHC-linked genes in autoimmune predisposition, notably including type I diabetes (Idd1 and Idd16) loci and chronic autoimmune thyroiditis (Ceat1) locus, on the non-obese diabetic (NOD) background. The R2 line is completely protected against type 1 diabetes.
Breeding history20 generations of backcrosses followed by sister-brother matings. Selection of subcongenics by additional backcrosses.
References
  • An interval tightly linked to but distinct from the H2 complex controls both overt diabetes (Idd16) and chronic experimental autoimmune thyroiditis (Ceat1) in nonobese diabetic mice.;Boulard Olivier, Damotte Diane, Deruytter Nathalie, Fluteau Guy, Carnaud Claude, Garchon Henri-Jean, ;2002;Diabetes;51;2141-7; 12086944
  • Mapping non-class II H2-linked loci for type 1 diabetes in nonobese diabetic mice.;Deruytter Nathalie, Boulard Olivier, Garchon Henri-Jean, ;2004;Diabetes;53;3323-7; 15561967

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased susceptibility to autoimmune diabetes / MGI
  • periinsulitis / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased hematocrit / MGI
  • abnormal liver physiology / MGI
  • abnormal T cell differentiation / MGI
  • abnormal cytokine secretion / MGI
  • increased autoantibody level / MGI
  • decreased susceptibility to parasitic infection / MGI
MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • abnormal liver physiology / MGI
  • abnormal T cell differentiation / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgM level / MGI
  • abnormal cytokine secretion / MGI
  • thyroid inflammation / MGI
  • increased autoantibody level / MGI
  • insulitis / MGI
  • increased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to parasitic infection / MGI
  • immune system phenotype / MGI
  • periinsulitis / MGI
  • abnormal T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • abnormal glucose homeostasis / MGI
  • periinsulitis / MGI
  • increased CD4-positive, alpha beta T cell number / MGI

Literature references

  • An interval tightly linked to but distinct from the H2 complex controls both overt diabetes (Idd16) and chronic experimental autoimmune thyroiditis (Ceat1) in nonobese diabetic mice.;Boulard Olivier, Damotte Diane, Deruytter Nathalie, Fluteau Guy, Carnaud Claude, Garchon Henri-Jean, ;2002;Diabetes;51;2141-7; 12086944
  • Mapping non-class II H2-linked loci for type 1 diabetes in nonobese diabetic mice.;Deruytter Nathalie, Boulard Olivier, Garchon Henri-Jean, ;2004;Diabetes;53;3323-7; 15561967

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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