C57BL/6NTac-Tmprss15^{tm1a(KOMP)Wtsi}/WtsiPh

Status	Available to order
EMMA ID	EM:13963
Citation information	RRID:IMSR_EM:13963 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Tmprss15^{tm1a(KOMP)Wtsi}/WtsiPh
Alternative name	EPD0079_6_H08
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Tmprss15^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Tmprss15
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0079_6_H08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic
Animals used for archiving	heterozygous C57BL/6NTac males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Congenital enteropathy due to enteropeptidase deficiency / Orphanet_168601

IMPC phenotypes (allele matching)

increased leukocyte cell number / IMPC
decreased body length / IMPC
decreased body weight / IMPC
increased blood urea nitrogen level / IMPC
increased circulating sodium level / IMPC
increased circulating amylase level / IMPC
decreased total body fat amount / IMPC
hyperplasia / IMPC
inflammation / IMPC

IMPC phenotypes (gene matching)

decreased body weight / IMPC
inflammation / IMPC
decreased total body fat amount / IMPC
increased circulating sodium level / IMPC
decreased body length / IMPC
hyperplasia / IMPC
increased leukocyte cell number / IMPC
increased circulating amylase level / IMPC
increased blood urea nitrogen level / IMPC

MGI phenotypes (allele matching)

decreased circulating HDL cholesterol level / MGI
increased leukocyte cell number / MGI
decreased body length / MGI
decreased body weight / MGI
decreased circulating alanine transaminase level / MGI
increased circulating chloride level / MGI
decreased circulating cholesterol level / MGI
increased mean corpuscular hemoglobin / MGI
increased blood urea nitrogen level / MGI
increased circulating sodium level / MGI
increased circulating amylase level / MGI
decreased total body fat amount / MGI

MGI phenotypes (gene matching)

decreased circulating HDL cholesterol level / MGI
increased leukocyte cell number / MGI
decreased body length / MGI
decreased body weight / MGI
decreased circulating alanine transaminase level / MGI
increased circulating chloride level / MGI
decreased circulating cholesterol level / MGI
increased mean corpuscular hemoglobin / MGI
increased blood urea nitrogen level / MGI
increased circulating sodium level / MGI
increased circulating amylase level / MGI
decreased total body fat amount / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6NTac-Tmprss15tm1a(KOMP)Wtsi/WtsiPh