NOD.B6-(D1Mit15-D1Mit359)/GhjCnrm

Status

Available to order

EMMA IDEM:01396
Citation informationRRID:IMSR_EM:01396 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameNOD.B6-(D1Mit15-D1Mit359)/GhjCnrm
Alternative nameNOD.B6-C1D(L2)
Strain typeSpontaneous
Allele/Transgene symbolNktcn1C57BL/6J, Fcgr2b
Gene/Transgene symbolNktcn1, Fcgr2b

Information from provider

ProviderHenri-Jean Garchon
Provider affiliationER70 CNRS et Unite 125 Inserm
Genetic informationNOD congenic strain with the distal chromosome 1 from C57BL/6 (line 2).
Phenotypic informationThis line bears the main QTL controlling serum levels of IgG1 and IgG2b in NOD mice. The main candidate is the Fcgr2 gene that codes for the low affinity type 2 receptor for IgG, whose expression is decreased by 90% in macrophages. This same interval also controls the severity of experimental arthritis, the number and the function of natural killer T cells, IgE serum levels, and an increased resistance to endotoxin shock.
Breeding history20 generations of backcrosses followed by sister-brother matings. Selection of subcongenics by additional backcrosses.
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • enlarged spleen / MGI
  • enlarged lymph nodes / MGI
  • decreased body weight / MGI
  • dehydration / MGI
  • hunched posture / MGI
  • anemia / MGI
  • abnormal seizure response to electrical stimulation / MGI
  • edema / MGI
  • increased inflammatory response / MGI
  • kidney inflammation / MGI
  • liver inflammation / MGI
  • lung inflammation / MGI
  • vasculitis / MGI
  • pancreas inflammation / MGI
  • salivary gland inflammation / MGI
  • premature death / MGI
  • abnormal hypersensitivity reaction / MGI
  • no abnormal phenotype detected / MGI
  • maximal tonic hindlimb extension seizures / MGI
  • abnormal mast cell physiology / MGI
  • increased immunoglobulin level / MGI
  • increased IgG level / MGI
  • increased IgM level / MGI
  • increased IgA level / MGI
  • glomerulonephritis / MGI
  • increased urine protein level / MGI
  • increased susceptibility to induced arthritis / MGI
  • tonic-clonic seizures / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-chromatin antibody level / MGI
  • decreased susceptibility to parasitic infection / MGI
  • skeleton phenotype / MGI
  • increased susceptibility to type I hypersensitivity reaction / MGI
  • increased germinal center B cell number / MGI
  • increased IgG1 level / MGI
  • increased IgG2a level / MGI
  • increased IgG2b level / MGI
  • increased IgG3 level / MGI
  • decreased B cell apoptosis / MGI
  • mortality/aging / MGI
  • renal glomerular protein deposits / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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