- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- decreased body weight / MGI
- dehydration / MGI
- hunched posture / MGI
- anemia / MGI
- abnormal seizure response to electrical stimulation / MGI
- edema / MGI
- increased inflammatory response / MGI
- kidney inflammation / MGI
- liver inflammation / MGI
- lung inflammation / MGI
- vasculitis / MGI
- pancreas inflammation / MGI
- salivary gland inflammation / MGI
- premature death / MGI
- abnormal hypersensitivity reaction / MGI
- no abnormal phenotype detected / MGI
- maximal tonic hindlimb extension seizures / MGI
- abnormal mast cell physiology / MGI
- increased immunoglobulin level / MGI
- increased IgG level / MGI
- increased IgM level / MGI
- increased IgA level / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- increased susceptibility to induced arthritis / MGI
- tonic-clonic seizures / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-chromatin antibody level / MGI
- decreased susceptibility to parasitic infection / MGI
- skeleton phenotype / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- increased germinal center B cell number / MGI
- increased IgG1 level / MGI
- increased IgG2a level / MGI
- increased IgG2b level / MGI
- increased IgG3 level / MGI
- decreased B cell apoptosis / MGI
- mortality/aging / MGI
- renal glomerular protein deposits / MGI
NOD.B6-(D1Mit15-D1Mit359)/GhjCnrm
Status | Available to order |
EMMA ID | EM:01396 |
International strain name | NOD.B6-(D1Mit15-D1Mit359)/GhjCnrm |
Alternative name | NOD.B6-C1D(L2) |
Strain type | Spontaneous |
Allele/Transgene symbol | Nktcn1C57BL/6J, Fcgr2b |
Gene/Transgene symbol | Nktcn1, Fcgr2b |
Information from provider
Provider | Henri-Jean Garchon |
Provider affiliation | ER70 CNRS et Unite 125 Inserm |
Genetic information | NOD congenic strain with the distal chromosome 1 from C57BL/6 (line 2). |
Phenotypic information | This line bears the main QTL controlling serum levels of IgG1 and IgG2b in NOD mice. The main candidate is the Fcgr2 gene that codes for the low affinity type 2 receptor for IgG, whose expression is decreased by 90% in macrophages. This same interval also controls the severity of experimental arthritis, the number and the function of natural killer T cells, IgE serum levels, and an increased resistance to endotoxin shock. |
Breeding history | 20 generations of backcrosses followed by sister-brother matings. Selection of subcongenics by additional backcrosses. |
References | None available |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
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