IMPC phenotypes (allele matching)
C57BL/6N-Phipem1(IMPC)Wtsi/WtsiCnbc
| Status | Available to order |
| EMMA ID | EM:13932 |
| International strain name | C57BL/6N-Phipem1(IMPC)Wtsi/WtsiCnbc |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Phipem1(IMPC)Wtsi |
| Gene/Transgene symbol | Phip |
Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome / Orphanet_589905
IMPC phenotypes (gene matching)
- abnormal cranium morphology / IMPC
- hyperactivity / IMPC
- abnormal embryo size / IMPC
- increased circulating aspartate transaminase level / IMPC
- preweaning lethality, complete penetrance / IMPC
- small uterus / IMPC
- enlarged urinary bladder / IMPC
- increased leukocyte cell number / IMPC
- decreased body length / IMPC
- decreased circulating chloride level / IMPC
- hydrocephalus / IMPC
- developmental dysplasia / IMPC
- hydrocephaly / IMPC
MGI phenotypes (gene matching)
- hypoglycemia / MGI
- abnormal hepatocyte morphology / MGI
- decreased body size / MGI
- premature death / MGI
- increased insulin sensitivity / MGI
- small myocardial fiber / MGI
- abnormal cell physiology / MGI
- abnormal lung epithelium morphology / MGI
- decreased total body fat amount / MGI
- postnatal lethality, incomplete penetrance / MGI