C57BL/6N-Rhbdf2^{em1(IMPC)Wtsi}/WtsiCnbc

Status	Available to order
EMMA ID	EM:13925
Citation information	RRID:IMSR_EM:13925 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Rhbdf2^{em1(IMPC)Wtsi}/WtsiCnbc
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Rhbdf2^{em1(IMPC)Wtsi}
Gene/Transgene symbol	Rhbdf2

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archiving	heterozygous C57BL/6N males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Palmoplantar keratoderma-esophageal carcinoma syndrome / Orphanet_2198

IMPC phenotypes (allele matching)

abnormal coat appearance / IMPC
abnormal hair growth / IMPC
abnormal vibrissa morphology / IMPC
increased mean corpuscular hemoglobin / IMPC
increased circulating magnesium level / IMPC

IMPC phenotypes (gene matching)

abnormal vibrissa morphology / IMPC
abnormal coat appearance / IMPC
decreased circulating alkaline phosphatase level / IMPC
abnormal response to tactile stimuli / IMPC
alopecia / IMPC
decreased circulating creatinine level / IMPC
increased circulating glucose level / IMPC
increased bone mineral content / IMPC
abnormal bone mineralization / IMPC
decreased bone mineral density / IMPC
decreased B cell number / IMPC
increased B cell number / IMPC
increased mean corpuscular hemoglobin / IMPC
trunk curl / IMPC
tremors / IMPC
increased total body fat amount / IMPC
decreased circulating HDL cholesterol level / IMPC
abnormal response to new environment / IMPC
abnormal hair growth / IMPC
increased circulating magnesium level / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6N-Rhbdf2em1(IMPC)Wtsi/WtsiCnbc