C57BL/6N-Rhbdf2em1(IMPC)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:13925
International strain nameC57BL/6N-Rhbdf2em1(IMPC)Wtsi/WtsiCnbc
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolRhbdf2em1(IMPC)Wtsi
Gene/Transgene symbolRhbdf2

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Palmoplantar keratoderma-esophageal carcinoma syndrome / Orphanet_2198
IMPC phenotypes (allele matching)
  • abnormal coat appearance / IMPC
  • abnormal hair growth / IMPC
  • abnormal vibrissa morphology / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • increased circulating magnesium level / IMPC
IMPC phenotypes (gene matching)
  • abnormal vibrissa morphology / IMPC
  • abnormal coat appearance / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • abnormal response to tactile stimuli / IMPC
  • alopecia / IMPC
  • decreased circulating creatinine level / IMPC
  • increased circulating glucose level / IMPC
  • increased bone mineral content / IMPC
  • abnormal bone mineralization / IMPC
  • decreased bone mineral density / IMPC
  • decreased B cell number / IMPC
  • increased B cell number / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • trunk curl / IMPC
  • tremors / IMPC
  • increased total body fat amount / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • abnormal response to new environment / IMPC
  • abnormal hair growth / IMPC
  • increased circulating magnesium level / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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