C57BL/6N-Phgdhem1(IMPC)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:13924
Citation informationRRID:IMSR_EM:13924 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Phgdhem1(IMPC)Wtsi/WtsiCnbc
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolPhgdhem1(IMPC)Wtsi
Gene/Transgene symbolPhgdh

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6N males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • hemorrhage / IMPC
  • abnormal blood vessel morphology / IMPC
  • microphthalmia / IMPC
  • prenatal lethality / IMPC
  • abnormal vitelline vasculature morphology / IMPC
  • decreased respiratory quotient / IMPC
  • decreased fluid intake / IMPC
  • embryonic growth retardation / IMPC
  • edema / IMPC
  • abnormal embryo development / IMPC
  • abnormal embryo size / IMPC
  • abnormal visceral yolk sac morphology / IMPC
  • abnormal hindbrain morphology / IMPC
  • abnormal head shape / IMPC
  • abnormal embryo turning / IMPC
  • unresponsive to tactile stimuli / IMPC
  • abnormal head size / IMPC
  • no spontaneous movement / IMPC
  • abnormal eye morphology / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased food intake / IMPC
MGI phenotypes (gene matching)
  • interdigital webbing / MGI
  • decreased brain size / MGI
  • forebrain hypoplasia / MGI
  • abnormal embryonic neuroepithelial layer differentiation / MGI
  • absent cerebellum / MGI
  • abnormal brain development / MGI
  • exencephaly / MGI
  • decreased embryo size / MGI
  • absent olfactory bulb / MGI
  • abnormal nervous system development / MGI
  • abnormal embryonic/fetal subventricular zone morphology / MGI
  • enlarged lateral ventricles / MGI
  • abnormal neuron differentiation / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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