C57BL/6N-Lrbaem1(IMPC)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:13918
Citation informationRRID:IMSR_EM:13918 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Lrbaem1(IMPC)Wtsi/WtsiOulu
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolLrbaem1(IMPC)Wtsi
Gene/Transgene symbolLrba

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • abnormal ear position / IMPC
  • increased circulating calcium level / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • decreased circulating chloride level / IMPC
  • increased circulating cholesterol level / IMPC
  • increased circulating creatinine level / IMPC
  • increased blood urea nitrogen level / IMPC
  • increased circulating total protein level / IMPC
  • absent pinna reflex / IMPC
  • increased circulating amylase level / IMPC
IMPC phenotypes (gene matching)
  • abnormal ear position / IMPC
  • increased circulating amylase level / IMPC
  • increased circulating calcium level / IMPC
  • absent pinna reflex / IMPC
  • increased blood urea nitrogen level / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • decreased circulating chloride level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased circulating total protein level / IMPC
  • increased circulating cholesterol level / IMPC
  • increased circulating creatinine level / IMPC
MGI phenotypes (gene matching)
  • increased length of allograft survival / MGI
  • increased regulatory T cell number / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased susceptibility to graft versus host disease / MGI
  • abnormal NK cell physiology / MGI
  • increased myeloid cell number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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