NOD.B6-Hc1/Cnrm

Status

Available to order

EMMA IDEM:01390
International strain nameNOD.B6-Hc1/Cnrm
Alternative nameNOD.B6-Hc
Strain typeSpontaneous
Allele/Transgene symbolHc1
Gene/Transgene symbolHc

Information from provider

ProviderHenri-Jean Garchon
Provider affiliationER70 CNRS et Unite 125 Inserm
Genetic informationA 2-base (TA) deletion at positions 62 and 63 of an 83-bases pair exon near the 5-prime end of the hemolytic complement (Hc) gene is found in the non-obese (NOD) but not in C57BL/6 strain, creating a null allele.
Phenotypic informationThe hemolytic complement is involved in a variety of immune reaction, including the lytic pathway of the complement and the production of anaphylatoxin, notably determining asthma susceptibility.
Breeding history12 generations of backcrosses.
References
  • Deficiency of the fifth component of complement in mice with an inherited complement defect.;Nilsson U R, Müller-Eberhard H J, ;1967;The Journal of experimental medicine;125;1-16; 4959665
  • Genetic influences on the end-stage effector phase of arthritis.;Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, Garchon H J, Degott C, Lathrop M, Benoist C, Mathis D, ;2001;The Journal of experimental medicine;194;321-30; 11489951

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased grip strength / IMPC
  • decreased fasting circulating glucose level / IMPC
MGI phenotypes (gene matching)
  • increased airway responsiveness / MGI
  • no abnormal phenotype detected / MGI
  • increased susceptibility to bacterial infection / MGI
  • liver fibrosis / MGI
  • decreased susceptibility to injury / MGI
  • homeostasis/metabolism phenotype / MGI

Literature references

  • Deficiency of the fifth component of complement in mice with an inherited complement defect.;Nilsson U R, Müller-Eberhard H J, ;1967;The Journal of experimental medicine;125;1-16; 4959665
  • Genetic influences on the end-stage effector phase of arthritis.;Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, Garchon H J, Degott C, Lathrop M, Benoist C, Mathis D, ;2001;The Journal of experimental medicine;194;321-30; 11489951

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).