IMPC phenotypes (gene matching)
NOD.B6-Hc1/Cnrm
| Status | Available to order |
| EMMA ID | EM:01390 |
| Citation information | RRID:IMSR_EM:01390 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | NOD.B6-Hc1/Cnrm |
| Alternative name | NOD.B6-Hc |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Hc1 |
| Gene/Transgene symbol | Hc |
Information from provider
| Provider | Henri-Jean Garchon |
| Provider affiliation | ER70 CNRS et Unite 125 Inserm |
| Genetic information | A 2-base (TA) deletion at positions 62 and 63 of an 83-bases pair exon near the 5-prime end of the hemolytic complement (Hc) gene is found in the non-obese (NOD) but not in C57BL/6 strain, creating a null allele. |
| Phenotypic information | The hemolytic complement is involved in a variety of immune reaction, including the lytic pathway of the complement and the production of anaphylatoxin, notably determining asthma susceptibility. |
| Breeding history | 12 generations of backcrosses. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Deficiency of the fifth component of complement in mice with an inherited complement defect.;Nilsson U R, Müller-Eberhard H J, ;1967;The Journal of experimental medicine;125;1-16; 4959665
- Genetic influences on the end-stage effector phase of arthritis.;Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, Garchon H J, Degott C, Lathrop M, Benoist C, Mathis D, ;2001;The Journal of experimental medicine;194;321-30; 11489951