B6.129-Ntn1Gt(IRESBetageo)1Pgr/Cnrm
Status | Available to order |
EMMA ID | EM:00139 |
International strain name | B6.129-Ntn1Gt(IRESBetageo)1Pgr/Cnrm |
Alternative name | Ntn1-gt |
Strain type | Gene-trap |
Allele/Transgene symbol | Ntn1Gt(IRESBetageo)1Pgr |
Gene/Transgene symbol | Ntn1 |
Information from provider
Provider | Peter Gruss |
Provider affiliation | Max Planck Inst. Biophysical Chemistry |
Genetic information | Insertion of the IRES-geo vector into the netrin 1 locus. |
Phenotypic information | Mutants lack two inner ear semicircular canals. |
Breeding history | Backcrossed to C57BL/6 (more than 7 backcross generations). |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial congenital mirror movements / Orphanet_238722
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal mammary gland development / MGI
- absent corpus callosum / MGI
- abnormal brain commissure morphology / MGI
- abnormal inner ear canal fusion / MGI
- altered righting response / MGI
- abnormal corticospinal tract morphology / MGI
- abnormal axon guidance / MGI
- absent lateral semicircular canal / MGI
- absent posterior semicircular canal / MGI
- abnormal locomotor coordination / MGI
- nervous system phenotype / MGI
- abnormal dorsal spinal root morphology / MGI
- hearing/vestibular/ear phenotype / MGI
- absent hippocampal commissure / MGI
- abnormal anterior commissure morphology / MGI
- absent gastric milk in neonates / MGI
- abnormal spinal cord dorsal column morphology / MGI
- abnormal pyramidal decussation morphology / MGI
- abnormal spinal cord central canal morphology / MGI
- abnormal spinal cord ventral commissure morphology / MGI
- abnormal spinal cord ependymal layer morphology / MGI
- postnatal lethality, complete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- abnormal pontine nuclei morphology / MGI
Literature references
- Netrin 1 is required for semicircular canal formation in the mouse inner ear.;Salminen M, Meyer B I, Bober E, Gruss P, ;2000;Development (Cambridge, England);127;13-22; 10654596
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