MGI phenotypes (allele matching)
B6.129-Ntn1Gt(IRESBetageo)1Pgr/Cnrm
| Status | Under development - register interest |
| EMMA ID | EM:00139 |
| Citation information | RRID:IMSR_EM:00139 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Ntn1Gt(IRESBetageo)1Pgr/Cnrm |
| Alternative name | Ntn1-gt |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Ntn1Gt(IRESBetageo)1Pgr |
| Gene/Transgene symbol | Ntn1 |
Information from provider
| Provider | Peter Gruss |
| Provider affiliation | Max Planck Inst. Biophysical Chemistry |
| Genetic information | Insertion of the IRES-geo vector into the netrin 1 locus. |
| Phenotypic information | Mutants lack two inner ear semicircular canals. |
| Breeding history | Backcrossed to C57BL/6 (more than 7 backcross generations). |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial congenital mirror movements / Orphanet_238722
MGI phenotypes (gene matching)
- abnormal mammary gland development / MGI
- absent corpus callosum / MGI
- abnormal brain commissure morphology / MGI
- abnormal inner ear canal fusion / MGI
- altered righting response / MGI
- abnormal corticospinal tract morphology / MGI
- abnormal axon guidance / MGI
- absent lateral semicircular canal / MGI
- absent posterior semicircular canal / MGI
- abnormal locomotor coordination / MGI
- nervous system phenotype / MGI
- abnormal dorsal spinal root morphology / MGI
- hearing/vestibular/ear phenotype / MGI
- absent hippocampal commissure / MGI
- abnormal anterior commissure morphology / MGI
- absent gastric milk in neonates / MGI
- abnormal spinal cord dorsal column morphology / MGI
- abnormal pyramidal decussation morphology / MGI
- abnormal spinal cord central canal morphology / MGI
- abnormal spinal cord ventral commissure morphology / MGI
- abnormal spinal cord ependymal layer morphology / MGI
- postnatal lethality, complete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- abnormal pontine nuclei morphology / MGI
Literature references
- Netrin 1 is required for semicircular canal formation in the mouse inner ear.;Salminen M, Meyer B I, Bober E, Gruss P, ;2000;Development (Cambridge, England);127;13-22; 10654596