C57BL/6N-Plcg2em1(IMPC)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:13892
Citation informationRRID:IMSR_EM:13892 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Plcg2em1(IMPC)Wtsi/WtsiCnbc
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolPlcg2em1(IMPC)Wtsi
Gene/Transgene symbolPlcg2

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6N males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • PLCG2-associated antibody deficiency and immune dysregulation / Orphanet_300359
    • Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation / Orphanet_324530
IMPC phenotypes (gene matching)
  • increased T cell number / IMPC
  • hyperactivity / IMPC
  • decreased hemoglobin content / IMPC
  • abnormal glucose homeostasis / IMPC
  • thrombocytosis / IMPC
  • decreased hematocrit / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased IgG3 level / IMPC
  • decreased mature B cell number / IMPC
  • decreased circulating free fatty acids level / IMPC
  • increased IgM level / IMPC
  • increased IgG1 level / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased bone mineral density / IMPC
  • increased IgG2b level / IMPC
  • decreased erythrocyte cell number / IMPC
MGI phenotypes (gene matching)
  • abnormal trabecular bone morphology / MGI
  • abnormal foot pad morphology / MGI
  • spleen hyperplasia / MGI
  • dermatitis / MGI
  • internal hemorrhage / MGI
  • abnormal humoral immune response / MGI
  • arrested B cell differentiation / MGI
  • decreased IgM level / MGI
  • abnormal inflammatory response / MGI
  • abnormal lymphatic vessel morphology / MGI
  • premature death / MGI
  • abnormal B cell differentiation / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal B cell physiology / MGI
  • chronic inflammation / MGI
  • glomerulonephritis / MGI
  • increased pre-B cell number / MGI
  • decreased susceptibility to induced arthritis / MGI
  • osteoarthritis / MGI
  • decreased osteoclast cell number / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased B cell proliferation / MGI
  • increased B cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal dendritic cell morphology / MGI
  • decreased B-1a cell number / MGI
  • decreased follicular B cell number / MGI
  • increased pro-B cell number / MGI
  • decreased transitional stage B cell number / MGI
  • decreased B-2 B cell number / MGI
  • decreased mature B cell number / MGI
  • abnormal osteoclast differentiation / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • increased B cell apoptosis / MGI
  • increased trabecular bone thickness / MGI
  • decreased platelet aggregation / MGI
  • increased transitional stage T2 B cell number / MGI
  • abnormal dendritic cell chemotaxis / MGI
  • abnormal NK cell physiology / MGI
  • increased trabecular bone volume / MGI
  • chylous ascites / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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