- abnormal aorta morphology / MGI
- abnormal head morphology / MGI
- abnormal blood vessel morphology / MGI
- poor circulation / MGI
- abnormal apoptosis / MGI
- hemorrhage / MGI
- intraventricular hemorrhage / MGI
- abnormal neuron morphology / MGI
- abnormal vitelline vasculature morphology / MGI
- abnormal cardinal vein morphology / MGI
- hemopericardium / MGI
- decreased heart rate / MGI
- abnormal vascular endothelial cell morphology / MGI
- increased vascular endothelial cell number / MGI
- hematoma / MGI
- decreased embryo weight / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- abnormal telencephalon development / MGI
B6.129-Braftm1Zim/Cnrm
Status | Available to order |
EMMA ID | EM:01389 |
International strain name | B6.129-Braftm1Zim/Cnrm |
Alternative name | Braf Knock-out |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Braftm1Zim |
Gene/Transgene symbol | Braf |
Information from provider
Provider | Leszek Wojnowski |
Provider affiliation | University Mainz |
Genetic information | See Wojnowski et al., Endothelial apoptosis in Braf-deficient mice. Nature Genetics, 16: 293-297 (1997) |
Phenotypic information | Mid-gestational lethality, due to defective angiogenesis. |
References |
|
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pilomyxoid astrocytoma / Orphanet_251615
- Classic hairy cell leukemia / Orphanet_58017
- Craniopharyngioma / Orphanet_54595
- Differentiated thyroid carcinoma / Orphanet_146
- Langerhans cell histiocytosis / Orphanet_389
- Cardiofaciocutaneous syndrome / Orphanet_1340
- Noonan syndrome with multiple lentigines / Orphanet_500
- Syringocystadenoma papilliferum / Orphanet_840
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal neurocranium morphology / MGI
- abnormal frontal bone morphology / MGI
- abnormal parietal bone morphology / MGI
- abnormal aorta morphology / MGI
- enlarged heart / MGI
- heart hyperplasia / MGI
- abnormal cell morphology / MGI
- abnormal head morphology / MGI
- shortened head / MGI
- abnormal thymus morphology / MGI
- decreased thymocyte number / MGI
- abnormal stratification in cerebral cortex / MGI
- abnormal visual cortex morphology / MGI
- abnormal somatosensory cortex morphology / MGI
- abnormal telencephalon development / MGI
- convulsive seizures / MGI
- decreased body weight / MGI
- decreased body size / MGI
- increased metastatic potential / MGI
- cataract / MGI
- abnormal mating frequency / MGI
- hyperactivity / MGI
- abnormal blood vessel morphology / MGI
- poor circulation / MGI
- abnormal apoptosis / MGI
- decreased embryo size / MGI
- abnormal placenta morphology / MGI
- abnormal placenta labyrinth morphology / MGI
- decreased white adipose tissue amount / MGI
- abnormal immune system physiology / MGI
- hemorrhage / MGI
- intraventricular hemorrhage / MGI
- increased lung adenoma incidence / MGI
- increased pheochromocytoma incidence / MGI
- premature death / MGI
- abnormal kidney morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal astrocyte morphology / MGI
- abnormal long term object recognition memory / MGI
- abnormal neuron morphology / MGI
- increased neuron apoptosis / MGI
- abnormal vitelline vasculature morphology / MGI
- oliguria / MGI
- thymus atrophy / MGI
- embryonic growth retardation / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- small placenta / MGI
- abnormal cardinal vein morphology / MGI
- decreased spleen weight / MGI
- decreased thymus weight / MGI
- abnormal trophoblast layer morphology / MGI
- hemopericardium / MGI
- decreased heart rate / MGI
- behavior/neurological phenotype / MGI
- tachypnea / MGI
- decreased creatinine clearance / MGI
- increased cardiac muscle contractility / MGI
- increased circulating noradrenaline level / MGI
- increased apoptosis / MGI
- abnormal vascular endothelial cell morphology / MGI
- increased vascular endothelial cell number / MGI
- thin cerebral cortex / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- hematoma / MGI
- abnormal pancreatic acinar cell morphology / MGI
- increased splenocyte apoptosis / MGI
- abnormal dermal melanocyte morphology / MGI
- decreased embryo weight / MGI
- abnormal skin sebaceous gland morphology / MGI
- increased thymocyte apoptosis / MGI
- abnormal cerebral cortex pyramidal cell morphology / MGI
- abnormal basicranium morphology / MGI
- increased gland tumor incidence / MGI
- postnatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- round head / MGI
Literature references
- Endothelial apoptosis in Braf-deficient mice.;Wojnowski L, Zimmer A M, Beck T W, Hahn H, Bernal R, Rapp U R, Zimmer A, ;1997;Nature genetics;16;293-7; 9207797
- Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.;Wojnowski L, Stancato L F, Larner A C, Rapp U R, Zimmer A, ;2000;Mechanisms of development;91;97-104; 10704835
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