B6.129-Braftm1Zim/Cnrm

Status

Available to order

EMMA IDEM:01389
Citation informationRRID:IMSR_EM:01389 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129-Braftm1Zim/Cnrm
Alternative nameBraf Knock-out
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolBraftm1Zim
Gene/Transgene symbolBraf

Information from provider

ProviderLeszek Wojnowski
Provider affiliationUniversity Mainz
Genetic informationSee Wojnowski et al., Endothelial apoptosis in Braf-deficient mice. Nature Genetics, 16: 293-297 (1997)
Phenotypic informationMid-gestational lethality, due to defective angiogenesis.
References
  • Endothelial apoptosis in Braf-deficient mice.;Wojnowski L, Zimmer A M, Beck T W, Hahn H, Bernal R, Rapp U R, Zimmer A, ;1997;Nature genetics;16;293-7; 9207797
  • Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.;Wojnowski L, Stancato L F, Larner A C, Rapp U R, Zimmer A, ;2000;Mechanisms of development;91;97-104; 10704835

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal aorta morphology / MGI
  • abnormal head morphology / MGI
  • abnormal blood vessel morphology / MGI
  • poor circulation / MGI
  • abnormal apoptosis / MGI
  • hemorrhage / MGI
  • intraventricular hemorrhage / MGI
  • abnormal neuron morphology / MGI
  • abnormal vitelline vasculature morphology / MGI
  • abnormal cardinal vein morphology / MGI
  • hemopericardium / MGI
  • decreased heart rate / MGI
  • abnormal vascular endothelial cell morphology / MGI
  • increased vascular endothelial cell number / MGI
  • hematoma / MGI
  • decreased embryo weight / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • abnormal telencephalon development / MGI
MGI phenotypes (gene matching)
  • abnormal neurocranium morphology / MGI
  • abnormal frontal bone morphology / MGI
  • abnormal parietal bone morphology / MGI
  • abnormal aorta morphology / MGI
  • enlarged heart / MGI
  • heart hyperplasia / MGI
  • abnormal cell morphology / MGI
  • abnormal head morphology / MGI
  • shortened head / MGI
  • abnormal thymus morphology / MGI
  • decreased thymocyte number / MGI
  • abnormal stratification in cerebral cortex / MGI
  • abnormal visual cortex morphology / MGI
  • abnormal somatosensory cortex morphology / MGI
  • abnormal telencephalon development / MGI
  • convulsive seizures / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • increased metastatic potential / MGI
  • cataract / MGI
  • abnormal mating frequency / MGI
  • hyperactivity / MGI
  • abnormal blood vessel morphology / MGI
  • poor circulation / MGI
  • abnormal apoptosis / MGI
  • decreased embryo size / MGI
  • abnormal placenta morphology / MGI
  • abnormal placenta labyrinth morphology / MGI
  • decreased white adipose tissue amount / MGI
  • abnormal immune system physiology / MGI
  • hemorrhage / MGI
  • intraventricular hemorrhage / MGI
  • increased lung adenoma incidence / MGI
  • increased pheochromocytoma incidence / MGI
  • premature death / MGI
  • abnormal kidney morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal astrocyte morphology / MGI
  • abnormal long term object recognition memory / MGI
  • abnormal neuron morphology / MGI
  • increased neuron apoptosis / MGI
  • abnormal vitelline vasculature morphology / MGI
  • oliguria / MGI
  • thymus atrophy / MGI
  • embryonic growth retardation / MGI
  • abnormal spongiotrophoblast layer morphology / MGI
  • small placenta / MGI
  • abnormal cardinal vein morphology / MGI
  • decreased spleen weight / MGI
  • decreased thymus weight / MGI
  • abnormal trophoblast layer morphology / MGI
  • hemopericardium / MGI
  • decreased heart rate / MGI
  • behavior/neurological phenotype / MGI
  • tachypnea / MGI
  • decreased creatinine clearance / MGI
  • increased cardiac muscle contractility / MGI
  • increased circulating noradrenaline level / MGI
  • increased apoptosis / MGI
  • abnormal vascular endothelial cell morphology / MGI
  • increased vascular endothelial cell number / MGI
  • thin cerebral cortex / MGI
  • abnormal placental labyrinth vasculature morphology / MGI
  • hematoma / MGI
  • abnormal pancreatic acinar cell morphology / MGI
  • increased splenocyte apoptosis / MGI
  • abnormal dermal melanocyte morphology / MGI
  • decreased embryo weight / MGI
  • abnormal skin sebaceous gland morphology / MGI
  • increased thymocyte apoptosis / MGI
  • abnormal cerebral cortex pyramidal cell morphology / MGI
  • abnormal basicranium morphology / MGI
  • increased gland tumor incidence / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • round head / MGI

Literature references

  • Endothelial apoptosis in Braf-deficient mice.;Wojnowski L, Zimmer A M, Beck T W, Hahn H, Bernal R, Rapp U R, Zimmer A, ;1997;Nature genetics;16;293-7; 9207797
  • Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.;Wojnowski L, Stancato L F, Larner A C, Rapp U R, Zimmer A, ;2000;Mechanisms of development;91;97-104; 10704835

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

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Legally binding conditions for the transfer

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