C57BL/6NCrl-Lrig3em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:13889
International strain nameC57BL/6NCrl-Lrig3em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolLrig3em1(IMPC)Ccpcz
Gene/Transgene symbolLrig3

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal vertebrae morphology / IMPC
  • abnormal heart morphology / IMPC
  • enlarged heart / IMPC
  • abnormal cranium morphology / IMPC
  • abnormal spleen morphology / IMPC
  • abnormal thymus morphology / IMPC
  • enlarged thymus / IMPC
  • abnormal skeletal muscle morphology / IMPC
  • abnormal gait / IMPC
  • male infertility / IMPC
  • female infertility / IMPC
  • abnormal skin morphology / IMPC
  • abnormal digit morphology / IMPC
  • increased circulating alanine transaminase level / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • increased kidney weight / IMPC
  • abnormal heart left ventricle morphology / IMPC
  • abnormal vertebral arch morphology / IMPC
  • increased circulating creatine kinase level / IMPC
  • increased circulating lactate dehydrogenase level / IMPC
IMPC phenotypes (gene matching)
  • abnormal spleen morphology / IMPC
  • increased circulating creatine kinase level / IMPC
  • enlarged heart / IMPC
  • abnormal gait / IMPC
  • male infertility / IMPC
  • enlarged thymus / IMPC
  • abnormal skin morphology / IMPC
  • increased circulating lactate dehydrogenase level / IMPC
  • increased kidney weight / IMPC
  • increased circulating alanine transaminase level / IMPC
  • abnormal heart morphology / IMPC
  • abnormal digit morphology / IMPC
  • abnormal cranium morphology / IMPC
  • abnormal thymus morphology / IMPC
  • abnormal skeletal muscle morphology / IMPC
  • female infertility / IMPC
  • abnormal vertebral arch morphology / IMPC
  • abnormal heart left ventricle morphology / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • abnormal vertebrae morphology / IMPC
MGI phenotypes (gene matching)
  • abnormal lateral semicircular canal morphology / MGI
  • decreased circulating HDL cholesterol level / MGI
  • abnormal craniofacial morphology / MGI
  • short snout / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • circling / MGI
  • increased heart rate / MGI
  • decreased circulating insulin level / MGI
  • increased systemic arterial blood pressure / MGI
  • no phenotypic analysis / MGI
  • decreased lateral semicircular canal size / MGI
  • decreased posterior semicircular canal size / MGI
  • decreased cardiac output / MGI
  • decreased circulating glycerol level / MGI
  • abnormal heart left ventricle morphology / MGI
  • abnormal ear development / MGI
  • head tossing / MGI
  • hearing/vestibular/ear phenotype / MGI
  • decreased cardiac stroke volume / MGI
  • abnormal heart left ventricle weight / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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