C57BL/6N-Nfkbizem1(IMPC)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:13885
Citation informationRRID:IMSR_EM:13885 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Nfkbizem1(IMPC)Wtsi/WtsiOulu
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolNfkbizem1(IMPC)Wtsi
Gene/Transgene symbolNfkbiz

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

MGI phenotypes (gene matching)
  • alopecia / MGI
  • enlarged spleen / MGI
  • enlarged lymph nodes / MGI
  • reddish skin / MGI
  • abnormal skin condition / MGI
  • scaly skin / MGI
  • dermatitis / MGI
  • thick skin / MGI
  • spontaneous skin ulceration / MGI
  • skin lesions / MGI
  • abnormal epidermal layer morphology / MGI
  • epidermal hyperplasia / MGI
  • hyperkeratosis / MGI
  • excessive scratching / MGI
  • skin edema / MGI
  • abnormal immune system physiology / MGI
  • eye inflammation / MGI
  • conjunctivitis / MGI
  • interstitial pneumonia / MGI
  • acanthosis / MGI
  • abnormal skin morphology / MGI
  • abnormal hair growth / MGI
  • abnormal T-helper 1 cell morphology / MGI
  • abnormal leukocyte physiology / MGI
  • increased immunoglobulin level / MGI
  • increased IgE level / MGI
  • abnormal lymphocyte morphology / MGI
  • abnormal immune system organ morphology / MGI
  • abnormal cytokine secretion / MGI
  • parakeratosis / MGI
  • skin inflammation / MGI
  • blepharitis / MGI
  • eyelid edema / MGI
  • abnormal tumor necrosis factor secretion / MGI
  • decreased interleukin-12 secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • abnormal lymph node cell ratio / MGI
  • lacrimal gland inflammation / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • abnormal conjunctiva goblet cell morphology / MGI
  • increased lacrimal gland apoptosis / MGI
  • perioral dermatitis / MGI
  • periocular dermatitis / MGI
  • decreased conjunctiva goblet cell number / MGI
  • corneal limbitis / MGI
  • decreased tear production / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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