IMPC phenotypes (allele matching)
- increased bone mineral content / IMPC
C57BL/6N-Pcdh15em1(IMPC)Wtsi/WtsiCnbc
| Status | Available to order |
| EMMA ID | EM:13880 |
| International strain name | C57BL/6N-Pcdh15em1(IMPC)Wtsi/WtsiCnbc |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Pcdh15em1(IMPC)Wtsi |
| Gene/Transgene symbol | Pcdh15 |
Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Usher syndrome type 1 / Orphanet_231169
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
IMPC phenotypes (gene matching)
- increased bone mineral content / IMPC
MGI phenotypes (gene matching)
- abnormal organ of Corti morphology / MGI
- organ of Corti degeneration / MGI
- decreased body size / MGI
- abnormal maternal nurturing / MGI
- ataxia / MGI
- circling / MGI
- bidirectional circling / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- head bobbing / MGI
- impaired swimming / MGI
- impaired righting response / MGI
- impaired balance / MGI
- postnatal growth retardation / MGI
- abnormal reflex / MGI
- deafness / MGI
- no abnormal phenotype detected / MGI
- abnormal cochlear hair cell morphology / MGI
- abnormal cochlear ganglion morphology / MGI
- cochlear ganglion degeneration / MGI
- abnormal otolith morphology / MGI
- enlarged otoliths / MGI
- absent tunnel of Corti / MGI
- abnormal cochlear sensory epithelium morphology / MGI
- cochlear ganglion hypoplasia / MGI
- abnormal pillar cell morphology / MGI
- abnormal organ of Corti supporting cell morphology / MGI
- abnormal Hensen cell morphology / MGI
- cochlear hair cell degeneration / MGI
- cochlear inner hair cell degeneration / MGI
- abnormal cochlear outer hair cell morphology / MGI
- cochlear outer hair cell degeneration / MGI
- abnormal orientation of outer hair cell stereociliary bundles / MGI
- abnormal orientation of inner hair cell stereociliary bundles / MGI
- abnormal cochlear hair cell stereociliary bundle morphology / MGI
- abnormal orientation of cochlear hair cell stereociliary bundles / MGI
- short cochlear hair cell stereocilia / MGI
- abnormal outer hair cell stereociliary bundle morphology / MGI
- decreased outer hair cell stereocilia number / MGI
- abnormal inner hair cell stereociliary bundle morphology / MGI
- fused inner hair cell stereocilia / MGI
- decreased inner hair cell stereocilia number / MGI
- abnormal cochlear hair cell inter-stereocilial links morphology / MGI
- abnormal cochlear hair bundle tip links morphology / MGI
- absent distortion product otoacoustic emissions / MGI
- absent linear vestibular evoked potential / MGI
- head tilt / MGI
- head tossing / MGI
- dystonia / MGI
- hearing/vestibular/ear phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal vestibular saccule morphology / MGI
- absent startle reflex / MGI
- retropulsion / MGI
- abnormal inner hair cell kinocilium morphology / MGI
- abnormal outer hair cell kinocilium morphology / MGI
- abnormal vestibular hair cell kinocilium morphology / MGI
- increased or absent threshold for auditory brainstem response / MGI