IMPC phenotypes (gene matching)
STOCK Rgs4tm1.1Jbr/Orl
| Status | Available to order |
| EMMA ID | EM:01388 |
| International strain name | STOCK Rgs4tm1.1Jbr/Orl |
| Alternative name | Rgs4lacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rgs4tm1.1Jbr |
| Gene/Transgene symbol | Rgs4 |
Information from provider
| Provider | Jean-François Brunet |
| Provider affiliation | CNRS/ Ecole normale supérieure |
| Genetic information | Produced by crossing the Rgs4loxFRTlacZ (see EMMA strain EM:01385) strain with a PGK-cre recombinase-expressing mouse strain. Expresses a Rgs4-lacZ fusion from the Rgs4 locus. |
| Phenotypic information | Subtle coordination deficit. Deficient central integration of pain. |
| Breeding history | Four backcrosses to C57BL/6. |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- decreased body weight / MGI
- impaired coordination / MGI
- abnormal touch/ nociception / MGI
- nervous system phenotype / MGI
- impaired behavioral response to morphine / MGI
- decreased behavioral withdrawal response / MGI
- embryonic lethality between somite formation and embryo turning, incomplete penetrance / MGI
MGI phenotypes (gene matching)
- decreased body weight / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- increased circulating HDL cholesterol level / MGI
- abnormal touch/ nociception / MGI
- no abnormal phenotype detected / MGI
- increased vertical activity / MGI
- no phenotypic analysis / MGI
- nervous system phenotype / MGI
- decreased aggression towards mice / MGI
- increased circulating cholesterol level / MGI
- behavior/neurological phenotype / MGI
- decreased renal plasma flow rate / MGI
- impaired conditioned place preference behavior / MGI
- impaired behavioral response to morphine / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- decreased behavioral withdrawal response / MGI
- increased total body fat amount / MGI
- embryonic lethality between somite formation and embryo turning, incomplete penetrance / MGI
Literature references
- Association and linkage analyses of RGS4 polymorphisms in schizophrenia.;Chowdari Kodavali V, Mirnics Karoly, Semwal Prachi, Wood Joel, Lawrence Elizabeth, Bhatia Triptish, Deshpande Smita N, B K Thelma, Ferrell Robert E, Middleton Frank A, Devlin Bernie, Levitt Pat, Lewis David A, Nimgaonkar Vishwajit L, ;2002;Human molecular genetics;11;1373-80; 12023979
- RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload.;Rogers J H, Tamirisa P, Kovacs A, Weinheimer C, Courtois M, Blumer K J, Kelly D P, Muslin A J, ;1999;The Journal of clinical investigation;104;567-76; 10487771
- Generation and characterization of Rgs4 mutant mice.;Grillet Nicolas, Pattyn Alexandre, Contet Candice, Kieffer Brigitte L, Goridis Christo, Brunet Jean-François, ;2005;Molecular and cellular biology;25;4221-8; 15870291