C57BL/6N-Sidt2em1(IMPC)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:13877
International strain nameC57BL/6N-Sidt2em1(IMPC)Wtsi/WtsiH
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolSidt2em1(IMPC)Wtsi
Gene/Transgene symbolSidt2

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased circulating LDL cholesterol level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • decreased circulating calcium level / IMPC
  • decreased circulating glycerol level / IMPC
  • decreased circulating iron level / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • thrombocytosis / IMPC
  • decreased circulating total protein level / IMPC
  • increased circulating amylase level / IMPC
IMPC phenotypes (gene matching)
  • increased circulating amylase level / IMPC
  • decreased circulating calcium level / IMPC
  • decreased circulating iron level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • decreased circulating total protein level / IMPC
  • decreased circulating glycerol level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • decreased circulating cholesterol level / IMPC
  • thrombocytosis / IMPC
  • decreased circulating LDL cholesterol level / IMPC
MGI phenotypes (gene matching)
  • abnormal liver morphology / MGI
  • abnormal hepatocyte morphology / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • increased circulating triglyceride level / MGI
  • hepatic necrosis / MGI
  • liver inflammation / MGI
  • no abnormal phenotype detected / MGI
  • hepatic steatosis / MGI
  • decreased circulating insulin level / MGI
  • increased circulating alanine transaminase level / MGI
  • liver fibrosis / MGI
  • abnormal insulin secretion / MGI
  • increased pancreatic beta cell number / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • impaired glucose tolerance / MGI
  • increased circulating aspartate transaminase level / MGI
  • homeostasis/metabolism phenotype / MGI
  • increased circulating glucose level / MGI
  • increased liver triglyceride level / MGI
  • abnormal endoplasmic reticulum morphology / MGI
  • increased liver free fatty acids level / MGI
  • increased endoplasmic reticulum stress / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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