C57BL/6N-Sidt2^{em1(IMPC)Wtsi}/WtsiH

Status	Available to order
EMMA ID	EM:13877
Citation information	RRID:IMSR_EM:13877 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Sidt2^{em1(IMPC)Wtsi}/WtsiH
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Sidt2^{em1(IMPC)Wtsi}
Gene/Transgene symbol	Sidt2

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)

decreased circulating LDL cholesterol level / IMPC
decreased circulating HDL cholesterol level / IMPC
decreased circulating calcium level / IMPC
decreased circulating glycerol level / IMPC
decreased circulating iron level / IMPC
decreased circulating cholesterol level / IMPC
increased circulating aspartate transaminase level / IMPC
thrombocytosis / IMPC
decreased circulating total protein level / IMPC
increased circulating amylase level / IMPC

IMPC phenotypes (gene matching)

increased circulating amylase level / IMPC
decreased circulating calcium level / IMPC
decreased circulating iron level / IMPC
decreased circulating HDL cholesterol level / IMPC
decreased circulating total protein level / IMPC
decreased circulating glycerol level / IMPC
increased circulating aspartate transaminase level / IMPC
decreased circulating cholesterol level / IMPC
thrombocytosis / IMPC
decreased circulating LDL cholesterol level / IMPC

MGI phenotypes (gene matching)

abnormal liver morphology / MGI
abnormal hepatocyte morphology / MGI
decreased body weight / MGI
decreased body size / MGI
increased circulating triglyceride level / MGI
hepatic necrosis / MGI
liver inflammation / MGI
no abnormal phenotype detected / MGI
hepatic steatosis / MGI
decreased circulating insulin level / MGI
increased circulating alanine transaminase level / MGI
liver fibrosis / MGI
abnormal insulin secretion / MGI
increased pancreatic beta cell number / MGI
abnormal pancreatic beta cell morphology / MGI
impaired glucose tolerance / MGI
increased circulating aspartate transaminase level / MGI
homeostasis/metabolism phenotype / MGI
increased circulating glucose level / MGI
increased liver triglyceride level / MGI
abnormal endoplasmic reticulum morphology / MGI
increased liver free fatty acids level / MGI
increased endoplasmic reticulum stress / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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