IMPC phenotypes (allele matching)
- increased circulating magnesium level / IMPC
C57BL/6N-Ifih1em1(IMPC)Wtsi/WtsiCnbc
| Status | Available to order |
| EMMA ID | EM:13835 |
| International strain name | C57BL/6N-Ifih1em1(IMPC)Wtsi/WtsiCnbc |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Ifih1em1(IMPC)Wtsi |
| Gene/Transgene symbol | Ifih1 |
Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Singleton-Merten dysplasia / Orphanet_85191
- Aicardi-Goutières syndrome / Orphanet_51
IMPC phenotypes (gene matching)
- increased circulating magnesium level / IMPC
MGI phenotypes (gene matching)
- abnormal leukocyte cell number / MGI
- increased granulocyte number / MGI
- mixed cellular infiltration to dermis / MGI
- postnatal growth retardation / MGI
- abnormal T cell activation / MGI
- autoimmune response / MGI
- increased inflammatory response / MGI
- liver inflammation / MGI
- postnatal lethality / MGI
- abnormal dendritic cell physiology / MGI
- increased susceptibility to viral infection / MGI
- abnormal dendritic cell antigen presentation / MGI
- increased immunoglobulin level / MGI
- increased IgG level / MGI
- increased IgM level / MGI
- increased IgA level / MGI
- glomerulonephritis / MGI
- abnormal cytokine secretion / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased susceptibility to systemic lupus erythematosus / MGI
- skin inflammation / MGI
- increased macrophage cell number / MGI
- abnormal cell physiology / MGI
- increased plasma cell number / MGI
- increased dendritic cell number / MGI
- decreased interferon-alpha secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal cytokine level / MGI
- abnormal chemokine level / MGI
- abnormal interferon level / MGI
- abnormal interleukin level / MGI
- decreased survivor rate / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal macrophage activation involved in immune response / MGI