B6.Cg-Pax9tm1.1(cre)Sbam/H
| Status | Available to order |
| EMMA ID | EM:13833 |
| International strain name | B6.Cg-Pax9tm1.1(cre)Sbam/H |
| Alternative name | Pax9-tm1.1(cre)Sbam (Pax9Cre) |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Pax9tm1.1(cre)Sbam |
| Gene/Transgene symbol | Pax9 |
Information from provider
| Provider | Simon Bamforth |
| Provider affiliation | Biosciences Institute, Newcastle University |
| Genetic information | The Pax9Cre targeting construct was designed to replace a 1.06 kb section of the Pax9 gene, spanning the second half of exon 2, containing the start codon, and the first half of the exon 3, containing the paired box and octapeptide motif, with a promoterless cre recombinase gene preceded by a consensus Kozak sequence. |
| Phenotypic information | Homozygous:Mice homozygous for Pax9Cre display the same phenotype as Pax9-/- mice (PMID: 31444215 and PMID: 9732271): cardiovascular, craniofacial, skeletal, thymus, parathyroid and ultimobranchial body developmental defects.Heterozygous:Pax9Cre heterozygous mice are normal. |
| Breeding history | Pax9Cre mice were backcrossed for at least 6 generations on to C57BL/6. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Oligodontia / Orphanet_99798
Literature references
- Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis.;Phillips Helen M, Stothard Catherine A, Shaikh Qureshi Wasay M, Kousa Anastasia I, Briones-Leon J Alberto, Khasawneh Ramada R, O'Loughlin Chloe, Sanders Rachel, Mazzotta Silvia, Dodds Rebecca, Seidel Kerstin, Bates Timothy, Nakatomi Mitsushiro, Cockell Simon J, Schneider Jürgen E, Mohun Timothy J, Maehr René, Kist Ralf, Peters Heiko, Bamforth Simon D, ;2019;Development (Cambridge, England);146;14; 31444215
- Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype.;Khasawneh Ramada R, Kist Ralf, Queen Rachel, Hussain Rafiqul, Coxhead Jonathan, Schneider Jürgen E, Mohun Timothy J, Zaffran Stéphane, Peters Heiko, Phillips Helen M, Bamforth Simon D, ;2021;BMC developmental biology;21;; 34615475
- Pax9 and Gbx2 Interact in the Pharyngeal Endoderm to Control Cardiovascular Development.;Stothard Catherine A, Mazzotta Silvia, Vyas Arjun, Schneider Jurgen E, Mohun Timothy J, Henderson Deborah J, Phillips Helen M, Bamforth Simon D, ;2020;Journal of cardiovascular development and disease;7;; 32466118