STOCK Tnfrsf19tm1.1(cre/ERT2)Cle/Ieg
| Status | Available to order |
| EMMA ID | EM:13831 |
| International strain name | STOCK Tnfrsf19tm1.1(cre/ERT2)Cle/Ieg |
| Alternative name | Troy-eGFP-IRES-CreERT2 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Tnfrsf19tm1.1(cre/ERT2)Cle |
| Gene/Transgene symbol | Tnfrsf19 |
Information from provider
| Provider | Hans Clevers |
| Provider affiliation | Hubrecht Instutite |
| Genetic information | The Troy-eGFP-IRES-CreERT2 transgenic mice express the fluorescence marker eGFP and the tamoxifen inducible recombinase (CreERT2) driven by the Tnfrsf19 (Troy) promotor. Mice were generated by homologous recombination by inserting an eGFP-IRES-CreERT2 cassette with a Neomycin cassette flanked by loxP sites into the translational start site (exon 2) of Tnfrsf19. |
| Phenotypic information | Homozygous:Homozygous Troy-eGFP-IRES-CreERT2 mice are phenotypically unaffected.Heterozygous:Heterozygous Troy-eGFP-IRES-CreERT2 mice are phenotypically unaffected. |
| Breeding history | The mice were generated with IB10/E14IB10 ES cells. Offsprings were bred to FlpO mice to remove the Neomycin resistance cassette. From then on mice were crossed as sib-matings. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | homozygous mixed |
Literature references
- Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.;Stange Daniel E, Koo Bon-Kyoung, Huch Meritxell, Sibbel Greg, Basak Onur, Lyubimova Anna, Kujala Pekka, Bartfeld Sina, Koster Jan, Geahlen Jessica H, Peters Peter J, van Es Johan H, van de Wetering Marc, Mills Jason C, Clevers Hans, ;2013;Cell;155;357-68; 24120136