C57BL/6N-Krt5^{em1(IMPC)Wtsi}/WtsiOulu

Status	Available to order
EMMA ID	EM:13823
Citation information	RRID:IMSR_EM:13823 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Krt5^{em1(IMPC)Wtsi}/WtsiOulu
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Krt5^{em1(IMPC)Wtsi}
Gene/Transgene symbol	Krt5

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	University of Oulu, Oulu, Finland

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Dowling-Degos disease / Orphanet_79145
Epidermolysis bullosa simplex, generalized intermediate / Orphanet_79399
Epidermolysis bullosa simplex, generalized severe / Orphanet_79396
Epidermolysis bullosa simplex with mottled pigmentation / Orphanet_79397
Epidermolysis bullosa simplex with circinate migratory erythema / Orphanet_158681
Localized epidermolysis bullosa simplex / Orphanet_79400

IMPC phenotypes (gene matching)

decreased body length / IMPC
preweaning lethality, complete penetrance / IMPC
preweaning lethality, incomplete penetrance / IMPC
abnormal lymph node morphology / IMPC

MGI phenotypes (gene matching)

abnormal esophageal epithelium morphology / MGI
abnormal stomach morphology / MGI
abnormal autopod morphology / MGI
abnormal tongue epithelium morphology / MGI
abnormal epidermal layer morphology / MGI
abnormal tail morphology / MGI
abnormal palate morphology / MGI
absent gastric milk in neonates / MGI
neonatal lethality, complete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6N-Krt5em1(IMPC)Wtsi/WtsiOulu