IMPC phenotypes (gene matching)
C57BL/6N-Cdk6tm1c(EUCOMM)Wtsi/TcpBiat
| Status | Available to order |
| EMMA ID | EM:13810 |
| International strain name | C57BL/6N-Cdk6tm1c(EUCOMM)Wtsi/TcpBiat |
| Alternative name | C57BL/6N-Cdk6 tm1c(EUCOMM)Wtsi/Tcp |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Cdk6tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Cdk6 |
Information from provider
| Provider | Veronika Sexl |
| Provider affiliation | Department of Biomedical Sciences, University of Veterinary Medicine |
| Genetic information | The mouse line C57BL/6N-Cdk6tm1c(EUCOMM)Wtsi/Tcp (referred to as Cdk6fl/fl) was generated with C57BL/6N-Cdk6tm1a(EUCOMM)Wtsi/Tcp (available from the Canadian Mouse Mutant Repository-CMMR at http://www.cmmr.ca/order.php?t=m&id=1766) made from EUCOMM ES cells (Bradley A, Anastassiadis K, Ayadi A, et al. The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome. 2012;23:580-586) at the Toronto Centre for Phenogenomics, Canada. |
| Phenotypic information | Homozygous:No data available; no phenotype expected.Heterozygous:No data available; no phenotype expected. |
| Breeding history | The flp recombinase-mediated excision was obtained by breeding a C57BL/6N-Cdk6tm1a(EUCOMM)Wtsi/Tcp heterozygous male with heterozygous C57BL/6N-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Tcp female(s). The mouse line was established by backcrossing Cdk6tm1c+/-; flp+/- mice to C57BL/6NCrl (less than 10 generations). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive primary microcephaly / Orphanet_2512
MGI phenotypes (gene matching)
- decreased leukocyte cell number / MGI
- abnormal spleen morphology / MGI
- small spleen / MGI
- spleen hypoplasia / MGI
- abnormal thymus morphology / MGI
- small thymus / MGI
- enlarged thymus / MGI
- increased thymocyte number / MGI
- decreased thymocyte number / MGI
- decreased body weight / MGI
- thymus hypoplasia / MGI
- reduced female fertility / MGI
- abnormal definitive hematopoiesis / MGI
- abnormal T cell differentiation / MGI
- abnormal spleen red pulp morphology / MGI
- abnormal hematopoietic system morphology/development / MGI
- abnormal lymphopoiesis / MGI
- abnormal erythrocyte morphology / MGI
- increased mean corpuscular volume / MGI
- decreased mature ovarian follicle number / MGI
- decreased erythrocyte cell number / MGI
- thymus atrophy / MGI
- abnormal thymocyte activation / MGI
- increased hematopoietic stem cell number / MGI
- decreased hematopoietic stem cell number / MGI
- decreased double-negative T cell number / MGI
- increased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- decreased T cell proliferation / MGI
- immune system phenotype / MGI
- increased mean corpuscular hemoglobin concentration / MGI
- increased T cell apoptosis / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased single-positive T cell number / MGI
- decreased megakaryocyte cell number / MGI
- decreased thymocyte apoptosis / MGI
- increased DN1 thymic pro-T cell number / MGI
- decreased DN1 thymic pro-T cell number / MGI
- decreased DN2 thymocyte number / MGI
- increased DN3 thymocyte number / MGI
- decreased DN4 thymocyte number / MGI
- abnormal hematopoietic stem cell physiology / MGI
- thymus cortex atrophy / MGI
Literature references
- Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system.;Maurer Barbara, Brandstoetter Tania, Kollmann Sebastian, Sexl Veronika, Prchal-Murphy Michaela, ;2021;Haematologica;106;2624-2632; 32855282