MGI phenotypes (allele matching)
B6.129-Zfp110tm1Mpin/Cnrm
| Status | Available to order |
| EMMA ID | EM:00138 |
| Citation information | RRID:IMSR_EM:00138 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Zfp110tm1Mpin/Cnrm |
| Alternative name | Nrif1-mut. |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Zfp110tm1Mpin |
| Gene/Transgene symbol | Zfp110 |
Information from provider
| Provider | Elisabeth Casademunt |
| Provider affiliation | Max Planck Inst. of Neurobiology |
| Genetic information | pGK-neo cassette replacing part of the last exon of the Zfp110 (Nrif1) gene. Replacement eliminates the putative p75 receptor-binding region of the ZFP110 (NRIF1) protein. |
| Phenotypic information | In a mixed B6129 background there are no major anatomical defects. However, the following traits have been observed: decrease in apoptotic levels in embryonic retina; abnormal whisker pad innervation; altered NFkB activation in Schwann cells; remarkable decrease in testis size (up to 70% in adults); slightly altered heat sensitivity. The mutation is embryonically lethal in a congenic B6 strain: homozygous mutant embryos do not survive beyond E12.5 |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death.;Casademunt E, Carter B D, Benzel I, Frade J M, Dechant G, Barde Y A, ;1999;The EMBO journal;18;6050-61; 10545116