IMPC phenotypes (gene matching)
- hyperplasia / IMPC
B6;129P2-Trex1tm1Tld/H
| Status | Available to order |
| EMMA ID | EM:13791 |
| International strain name | B6;129P2-Trex1tm1Tld/H |
| Alternative name | Trex1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Trex1tm1Tld |
| Gene/Transgene symbol | Trex1 |
Information from provider
| Provider | Thomas Lindahl |
| Provider affiliation | Cancer Research UK London Research Institute |
| Genetic information | Knock-out of Trex1. |
| Phenotypic information | Homozygous:Typical null phenotype of auricular thrombus, cardiomyopathy, and circulatory failure. Dramatically increased morbidity of Trex1 null mice postweaning. See Morita M. et al., 2004 (PubMed ID:15254239).Heterozygous:No significant difference in phenotype from parental strain. See Morita M. et al., 2004 (PubMed ID:15254239). |
| Breeding history | The mice were produced on a mixed background, 129 x B6 and bred to C57BL/6J or intercrossed. The mice have not been significantly backcrossed (estimated 3-4 generations to C57BL/6) or inbred. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease.;Lindahl Tomas, Barnes Deborah E, Yang Yun-Gui, Robins Peter, ;2009;Biochemical Society transactions;37;535-8; 19442247
- Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.;Rice Gillian, Newman William G, Dean John, Patrick Teresa, Parmar Rekha, Flintoff Kim, Robins Peter, Harvey Scott, Hollis Thomas, O'Hara Ann, Herrick Ariane L, Bowden Andrew P, Perrino Fred W, Lindahl Tomas, Barnes Deborah E, Crow Yanick J, ;2007;American journal of human genetics;80;811-5; 17357087
- Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.;Morita Masashi, Stamp Gordon, Robins Peter, Dulic Anna, Rosewell Ian, Hrivnak Geza, Daly Graham, Lindahl Tomas, Barnes Deborah E, ;2004;Molecular and cellular biology;24;6719-27; 15254239
- Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.;Yang Yun-Gui, Lindahl Tomas, Barnes Deborah E, ;2007;Cell;131;873-86; 18045533