C57BL/6N-Klf1em1(IMPC)Wtsi/WtsiIeg

Status

Available to order

EMMA IDEM:13779
International strain nameC57BL/6N-Klf1em1(IMPC)Wtsi/WtsiIeg
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolKlf1em1(IMPC)Wtsi
Gene/Transgene symbolKlf1

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome / Orphanet_46532
    • Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome / Orphanet_251380
    • Congenital dyserythropoietic anemia type IV / Orphanet_293825
MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • abnormal erythropoiesis / MGI
  • small liver / MGI
  • pale liver / MGI
  • enlarged spleen / MGI
  • anemia / MGI
  • impaired hematopoiesis / MGI
  • abnormal erythrocyte morphology / MGI
  • anisocytosis / MGI
  • poikilocytosis / MGI
  • decreased hemoglobin content / MGI
  • decreased erythrocyte cell number / MGI
  • abnormal erythrocyte osmotic lysis / MGI
  • pallor / MGI
  • abnormal embryonic erythrocyte morphology / MGI
  • abnormal proximal convoluted tubule morphology / MGI
  • increased spleen weight / MGI
  • erythroblastosis / MGI
  • polychromatophilia / MGI
  • hematopoietic system phenotype / MGI
  • decreased mean corpuscular hemoglobin / MGI
  • increased liver iron level / MGI
  • increased spleen iron level / MGI
  • increased nucleated erythrocyte cell number / MGI
  • increased kidney iron level / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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