C57BL/6N-Il4raem1(IMPC)Wtsi/WtsiIeg

Status

Available to order

EMMA IDEM:13775
Citation informationRRID:IMSR_EM:13775 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Il4raem1(IMPC)Wtsi/WtsiIeg
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolIl4raem1(IMPC)Wtsi
Gene/Transgene symbolIl4ra

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal microglial cell morphology / MGI
  • increased monocyte cell number / MGI
  • abnormal intestinal epithelium morphology / MGI
  • abnormal crypts of Lieberkuhn morphology / MGI
  • weight loss / MGI
  • abnormal immune system physiology / MGI
  • altered susceptibility to infection / MGI
  • liver inflammation / MGI
  • increased airway responsiveness / MGI
  • premature death / MGI
  • abnormal bronchus morphology / MGI
  • respiratory system inflammation / MGI
  • increased susceptibility to infection / MGI
  • abnormal T-helper 2 cell morphology / MGI
  • abnormal macrophage physiology / MGI
  • decreased IgE level / MGI
  • increased IgG level / MGI
  • increased IgE level / MGI
  • granulomatous inflammation / MGI
  • abnormal immune serum protein physiology / MGI
  • abnormal cytokine secretion / MGI
  • impaired macrophage chemotaxis / MGI
  • increased eosinophil cell number / MGI
  • increased susceptibility to parasitic infection / MGI
  • decreased T cell proliferation / MGI
  • abnormal T-helper 2 physiology / MGI
  • increased susceptibility to type I hypersensitivity reaction / MGI
  • decreased T-helper 2 cell number / MGI
  • decreased IgG1 level / MGI
  • increased IgG2a level / MGI
  • abnormal circulating interferon-gamma level / MGI
  • increased circulating interleukin-4 level / MGI
  • decreased interleukin-10 secretion / MGI
  • increased interleukin-4 secretion / MGI
  • decreased interleukin-4 secretion / MGI
  • decreased interleukin-5 secretion / MGI
  • increased transforming growth factor level / MGI
  • abnormal circulating cytokine level / MGI
  • increased respiratory mucosa goblet cell number / MGI
  • abnormal macrophage activation involved in immune response / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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