- abnormal microglial cell morphology / MGI
- increased monocyte cell number / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal crypts of Lieberkuhn morphology / MGI
- weight loss / MGI
- abnormal immune system physiology / MGI
- altered susceptibility to infection / MGI
- liver inflammation / MGI
- increased airway responsiveness / MGI
- premature death / MGI
- abnormal bronchus morphology / MGI
- respiratory system inflammation / MGI
- increased susceptibility to infection / MGI
- abnormal T-helper 2 cell morphology / MGI
- abnormal macrophage physiology / MGI
- decreased IgE level / MGI
- increased IgG level / MGI
- increased IgE level / MGI
- granulomatous inflammation / MGI
- abnormal immune serum protein physiology / MGI
- abnormal cytokine secretion / MGI
- impaired macrophage chemotaxis / MGI
- increased eosinophil cell number / MGI
- increased susceptibility to parasitic infection / MGI
- decreased T cell proliferation / MGI
- abnormal T-helper 2 physiology / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- decreased T-helper 2 cell number / MGI
- decreased IgG1 level / MGI
- increased IgG2a level / MGI
- abnormal circulating interferon-gamma level / MGI
- increased circulating interleukin-4 level / MGI
- decreased interleukin-10 secretion / MGI
- increased interleukin-4 secretion / MGI
- decreased interleukin-4 secretion / MGI
- decreased interleukin-5 secretion / MGI
- increased transforming growth factor level / MGI
- abnormal circulating cytokine level / MGI
- increased respiratory mucosa goblet cell number / MGI
- abnormal macrophage activation involved in immune response / MGI
C57BL/6N-Il4raem1(IMPC)Wtsi/WtsiIeg
Status | Available to order |
EMMA ID | EM:13775 |
International strain name | C57BL/6N-Il4raem1(IMPC)Wtsi/WtsiIeg |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Il4raem1(IMPC)Wtsi |
Gene/Transgene symbol | Il4ra |
Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).