strain-details - INFRAFRONTIER

Information from provider

Status	Under development - register interest
EMMA ID	EM:13773
International strain name	C57BL/6NCrl-Kcnn4^{em1(IMPC)Ccpcz}/Ph
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Kcnn4^{em1(IMPC)Ccpcz}
Gene/Transgene symbol	Kcnn4

Provider	Institute of Molecular Genetics
Provider affiliation	Department of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Disease and phenotype information

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

Orphanet associated rare diseases, based on orthologous gene matching

Dehydrated hereditary stomatocytosis / Orphanet_3202

IMPC phenotypes (allele matching)

abnormal heart morphology / IMPC
abnormal rectum morphology / IMPC
abnormal colon morphology / IMPC
abnormal liver morphology / IMPC
small liver / IMPC
abnormal spleen morphology / IMPC
enlarged spleen / IMPC
abnormal thymus morphology / IMPC
small thymus / IMPC
enlarged thymus / IMPC
abnormal testis morphology / IMPC
enlarged testis / IMPC
small seminal vesicle / IMPC
decreased exploration in new environment / IMPC
abnormal seminal vesicle morphology / IMPC
abnormal skin morphology / IMPC
abnormal tooth morphology / IMPC
small heart / IMPC
decreased hemoglobin content / IMPC
decreased erythrocyte cell number / IMPC
abnormal joint morphology / IMPC
increased spleen weight / IMPC
enlarged cecum / IMPC
hydrometra / IMPC
increased red blood cell distribution width / IMPC
increased fasting circulating glucose level / IMPC
increased freezing behavior / IMPC

IMPC phenotypes (gene matching)

enlarged cecum / IMPC
small thymus / IMPC
increased spleen weight / IMPC
small liver / IMPC
abnormal skin morphology / IMPC
abnormal testis morphology / IMPC
increased red blood cell distribution width / IMPC
enlarged thymus / IMPC
abnormal rectum morphology / IMPC
decreased exploration in new environment / IMPC
abnormal spleen morphology / IMPC
decreased hemoglobin content / IMPC
abnormal tooth morphology / IMPC
abnormal liver morphology / IMPC
abnormal colon morphology / IMPC
abnormal joint morphology / IMPC
increased fasting circulating glucose level / IMPC
increased freezing behavior / IMPC
abnormal seminal vesicle morphology / IMPC
enlarged testis / IMPC
abnormal thymus morphology / IMPC
hydrometra / IMPC
small seminal vesicle / IMPC
decreased erythrocyte cell number / IMPC
enlarged spleen / IMPC
abnormal heart morphology / IMPC
small heart / IMPC

MGI phenotypes (gene matching)

abnormal systemic arterial blood pressure / MGI
macrocytosis / MGI
abnormal heart morphology / MGI
enlarged spleen / MGI
abnormal hematopoietic system physiology / MGI
abnormal digestive system physiology / MGI
abnormal T cell physiology / MGI
increased mean corpuscular volume / MGI
increased hematocrit / MGI
increased heart weight / MGI
renal interstitial fibrosis / MGI
abnormal erythrocyte osmotic lysis / MGI
abnormal heart left ventricle morphology / MGI
increased mean systemic arterial blood pressure / MGI
increased spleen weight / MGI
decreased susceptibility to injury / MGI
decreased vasodilation / MGI
increased systemic arterial diastolic blood pressure / MGI
increased systemic arterial systolic blood pressure / MGI
increased spleen iron level / MGI
increased hemoglobin concentration distribution width / MGI
increased parotid gland size / MGI
abnormal red blood cell deformability / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

C57BL/6NCrl-Kcnn4^{em1(IMPC)Ccpcz}/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Kcnn4em1(IMPC)Ccpcz/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Kcnn4^{em1(IMPC)Ccpcz}/Ph