C57BL/6N-Esr1em1(IMPC)Wtsi/WtsiIeg

Status

Available to order

EMMA IDEM:13748
International strain nameC57BL/6N-Esr1em1(IMPC)Wtsi/WtsiIeg
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolEsr1em1(IMPC)Wtsi
Gene/Transgene symbolEsr1

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • increased white adipose tissue amount / MGI
  • increased bone mineral density / MGI
  • decreased bone mineral density / MGI
  • decreased compact bone thickness / MGI
  • abnormal vertebrae morphology / MGI
  • abnormal bone marrow cell number / MGI
  • impaired fertilization / MGI
  • cortical renal glomerulopathies / MGI
  • abnormal mammary gland development / MGI
  • abnormal branching of the mammary ductal tree / MGI
  • decreased thymocyte number / MGI
  • abnormal hypothalamus morphology / MGI
  • abnormal uterus morphology / MGI
  • uterus hypoplasia / MGI
  • abnormal ovary morphology / MGI
  • impaired ovarian folliculogenesis / MGI
  • abnormal ovarian folliculogenesis / MGI
  • abnormal ovarian follicle morphology / MGI
  • absent mature ovarian follicles / MGI
  • absent corpus luteum / MGI
  • abnormal vagina morphology / MGI
  • abnormal vagina epithelium morphology / MGI
  • abnormal testis morphology / MGI
  • seminiferous tubule degeneration / MGI
  • abnormal spermatogenesis / MGI
  • decreased body length / MGI
  • increased body weight / MGI
  • obese / MGI
  • decreased body weight / MGI
  • increased body size / MGI
  • increased aggression towards mice / MGI
  • increased aggression towards females / MGI
  • abnormal social investigation / MGI
  • abnormal mating receptivity / MGI
  • reduced male mating frequency / MGI
  • abnormal pup retrieval / MGI
  • pup cannibalization / MGI
  • abnormal maternal nurturing / MGI
  • hyperactivity / MGI
  • abnormal skeleton physiology / MGI
  • abnormal osteoclast physiology / MGI
  • increased circulating HDL cholesterol level / MGI
  • abnormal vasodilation / MGI
  • failure of embryo implantation / MGI
  • increased circulating follicle stimulating hormone level / MGI
  • increased circulating luteinizing hormone level / MGI
  • thymus hypoplasia / MGI
  • reduced male fertility / MGI
  • infertility / MGI
  • male infertility / MGI
  • female infertility / MGI
  • ovary cysts / MGI
  • abnormal skeleton development / MGI
  • abnormal definitive hematopoiesis / MGI
  • abnormal kidney physiology / MGI
  • abnormal B cell differentiation / MGI
  • abnormal reproductive system morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal innervation / MGI
  • abnormal seminiferous tubule morphology / MGI
  • abnormal B cell number / MGI
  • abnormal immunoglobulin level / MGI
  • increased vertical activity / MGI
  • abnormal epididymis morphology / MGI
  • small uterus / MGI
  • asthenozoospermia / MGI
  • oligozoospermia / MGI
  • abnormal nociception after inflammation / MGI
  • glomerulonephritis / MGI
  • decreased vertical activity / MGI
  • short tibia / MGI
  • decreased circulating testosterone level / MGI
  • increased circulating testosterone level / MGI
  • decreased heart weight / MGI
  • increased growth rate / MGI
  • albuminuria / MGI
  • abnormal bone mineralization / MGI
  • increased urine protein level / MGI
  • no phenotypic analysis / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • abnormal cell migration / MGI
  • short femur / MGI
  • testicular atrophy / MGI
  • decreased ovulation rate / MGI
  • impaired granulosa cell differentiation / MGI
  • abnormal uterus development / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • abnormal male reproductive system physiology / MGI
  • abnormal female reproductive system physiology / MGI
  • abnormal thymus physiology / MGI
  • abnormal bone structure / MGI
  • decreased aggression towards males / MGI
  • decreased aggression towards mice / MGI
  • impaired passive avoidance behavior / MGI
  • abnormal vascular endothelial cell physiology / MGI
  • decreased bone mass / MGI
  • short ulna / MGI
  • altered response of heart to induced stress / MGI
  • decreased length of long bones / MGI
  • decreased circulating insulin-like growth factor I level / MGI
  • abnormal efferent ductules of testis morphology / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • abnormal class switch recombination / MGI
  • ovary hemorrhage / MGI
  • abnormal testis weight / MGI
  • decreased testis weight / MGI
  • abnormal vascular wound healing / MGI
  • decreased energy expenditure / MGI
  • abnormal endometrium morphology / MGI
  • decreased male germ cell number / MGI
  • increased uterus weight / MGI
  • decreased uterus weight / MGI
  • enlarged uterus / MGI
  • abnormal epididymis epithelium morphology / MGI
  • decreased thymus weight / MGI
  • increased osteoclast cell number / MGI
  • decreased osteoblast cell number / MGI
  • decreased bone strength / MGI
  • decreased B cell number / MGI
  • increased double-positive T cell number / MGI
  • decreased circulating prolactin level / MGI
  • increased luteinizing hormone level / MGI
  • increased circulating cholesterol level / MGI
  • decreased circulating estradiol level / MGI
  • increased circulating estradiol level / MGI
  • decreased circulating progesterone level / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • adipose tissue phenotype / MGI
  • growth/size/body region phenotype / MGI
  • cardiovascular system phenotype / MGI
  • behavior/neurological phenotype / MGI
  • reproductive system phenotype / MGI
  • skeleton phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal circulating protein level / MGI
  • hyporesponsive to tactile stimuli / MGI
  • increased circulating glucose level / MGI
  • teratozoospermia / MGI
  • decreased lung weight / MGI
  • abnormal pituitary gland physiology / MGI
  • decreased aggression / MGI
  • increased circulating leptin level / MGI
  • decreased long bone epiphyseal plate size / MGI
  • abnormal rete testis morphology / MGI
  • dilated rete testis / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • increased plasma cell number / MGI
  • decreased mature B cell number / MGI
  • decreased immature B cell number / MGI
  • decreased lactotroph cell number / MGI
  • increased spleen germinal center number / MGI
  • abnormal mesonephros morphology / MGI
  • increased IgG3 level / MGI
  • abnormal spleen physiology / MGI
  • abnormal lymph node cell ratio / MGI
  • anovulation / MGI
  • abnormal physiological response to xenobiotic / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • detached sperm flagellum / MGI
  • vagina hypoplasia / MGI
  • absent estrous cycle / MGI
  • uterus cysts / MGI
  • endometrium hyperplasia / MGI
  • decreased endometrial gland number / MGI
  • increased white fat cell size / MGI
  • increased white fat cell number / MGI
  • dilated efferent ductules of testis / MGI
  • abnormal internal male genitalia morphology / MGI
  • enlarged endometrial glands / MGI
  • dilated seminiferous tubules / MGI
  • abnormal bone marrow cell physiology / MGI
  • increased gonadal fat pad weight / MGI
  • increased epididymal fat pad weight / MGI
  • increased inguinal fat pad weight / MGI
  • increased mammary fat pad weight / MGI
  • increased parametrial fat pad weight / MGI
  • increased renal fat pad weight / MGI
  • increased retroperitoneal fat pad weight / MGI
  • abnormal secondary ovarian follicle morphology / MGI
  • increased theca cell number / MGI
  • ovarian follicular cyst / MGI
  • abnormal superovulation / MGI
  • abnormal uterus physiology / MGI
  • decreased birth weight / MGI
  • abnormal chondrocyte physiology / MGI
  • spermatic granuloma / MGI
  • failure of ejaculation / MGI
  • increased total body fat amount / MGI
  • decreased bone mineral content / MGI
  • increased compact bone area / MGI
  • decreased compact bone area / MGI
  • decreased primordial ovarian follicle number / MGI
  • renal glomerulus hypertrophy / MGI
  • expanded mesangial matrix / MGI
  • abnormal seminiferous tubule epithelium morphology / MGI
  • abnormal cremaster muscle morphology / MGI
  • abnormal volumetric bone mineral density / MGI
  • increased volumetric bone mineral density / MGI
  • decreased volumetric bone mineral density / MGI
  • decreased areal bone mineral density / MGI
  • decreased bone ossification / MGI
  • decreased bone mineralization / MGI
  • renal glomerular immunoglobulin deposits / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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