C57BL/6-Tg(Prox1-cre/ERT2)1Tmak/H

Status	Available to order
EMMA ID	EM:13737
Citation information	RRID:IMSR_EM:13737 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6-Tg(Prox1-cre/ERT2)1Tmak/H
Alternative name	Prox1-CreERT2
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Prox1-cre/ERT2)1Tmak
Gene/Transgene symbol	Tg(Prox1-cre/ERT2)1Tmak

Information from provider

Provider	Taija Makinen
Provider affiliation	Lymphatic Development Laboratory, Uppsala University
Genetic information	A cDNA encoding tamoxifen inducible Cre recombinase (CreERT2) followed by SV40 polyadenylation signal was introduced into the start codon of Prox1 in BAC clone RP23-190F21 using homologous recombination in bacteria.
Phenotypic information	Homozygous: Phenotypically normal Heterozygous: Phenotypically normal
Breeding history	Congenic
References	Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.;Bazigou Eleni, Lyons Oliver T A, Smith Alberto, Venn Graham E, Cope Celia, Brown Nigel A, Makinen Taija, ;2011;The Journal of clinical investigation;121;2984-92; 21765212 MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell-Suppressive Functions.;Gkountidi Anastasia O, Garnier Laure, Dubrot Juan, Angelillo Julien, Harlé Guillaume, Brighouse Dale, Wrobel Ludovic J, Pick Robert, Scheiermann Christoph, Swartz Melody A, Hugues Stéphanie, ;2021;Cancer immunology research;9;748-764; 33952631 Absence of MHC-II expression by lymph node stromal cells results in autoimmunity.;Dubrot Juan, Duraes Fernanda V, Harlé Guillaume, Schlaeppi Anjalie, Brighouse Dale, Madelon Natacha, Göpfert Christine, Stokar-Regenscheit Nadine, Acha-Orbea Hans, Reith Walter, Gannagé Monique, Hugues Stephanie, ;2018;Life science alliance;1;e201800164; 30584641 The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling.;Carlantoni Claudia, Liekfeld Leon M H, Hemkemeyer Sandra A, Schreier Danny, Saygi Ceren, Kurelic Roberta, Cardarelli Silvia, Kalucka Joanna, Schulte Christian, Beerens Manu, Mailer Reiner K, Schäffer Tilman E, Naro Fabio, Pellegrini Manuela, Nikolaev Viacheslav O, Renné Thomas, Frye Maike, ;2024;Developmental cell;59;308-325.e11; 38159569
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.;Bazigou Eleni, Lyons Oliver T A, Smith Alberto, Venn Graham E, Cope Celia, Brown Nigel A, Makinen Taija, ;2011;The Journal of clinical investigation;121;2984-92; 21765212
MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell-Suppressive Functions.;Gkountidi Anastasia O, Garnier Laure, Dubrot Juan, Angelillo Julien, Harlé Guillaume, Brighouse Dale, Wrobel Ludovic J, Pick Robert, Scheiermann Christoph, Swartz Melody A, Hugues Stéphanie, ;2021;Cancer immunology research;9;748-764; 33952631
Absence of MHC-II expression by lymph node stromal cells results in autoimmunity.;Dubrot Juan, Duraes Fernanda V, Harlé Guillaume, Schlaeppi Anjalie, Brighouse Dale, Madelon Natacha, Göpfert Christine, Stokar-Regenscheit Nadine, Acha-Orbea Hans, Reith Walter, Gannagé Monique, Hugues Stephanie, ;2018;Life science alliance;1;e201800164; 30584641
The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling.;Carlantoni Claudia, Liekfeld Leon M H, Hemkemeyer Sandra A, Schreier Danny, Saygi Ceren, Kurelic Roberta, Cardarelli Silvia, Kalucka Joanna, Schulte Christian, Beerens Manu, Mailer Reiner K, Schäffer Tilman E, Naro Fabio, Pellegrini Manuela, Nikolaev Viacheslav O, Renné Thomas, Frye Maike, ;2024;Developmental cell;59;308-325.e11; 38159569

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