C57BL/6-Tg(Prox1-cre/ERT2)1Tmak/H

Status

Available to order

EMMA IDEM:13737
International strain nameC57BL/6-Tg(Prox1-cre/ERT2)1Tmak/H
Alternative nameProx1-CreERT2
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Prox1-cre/ERT2)1Tmak,
Gene/Transgene symbolTg(Prox1-cre/ERT2)1Tmak

Information from provider

ProviderTaija Makinen
Provider affiliationLymphatic Development Laboratory, Uppsala University
Genetic informationA cDNA encoding tamoxifen inducible Cre recombinase (CreERT2) followed by SV40 polyadenylation signal was introduced into the start codon of Prox1 in BAC clone RP23-190F21 using homologous recombination in bacteria.
Phenotypic informationHomozygous:
Phenotypically normal

Heterozygous:
Phenotypically normal
Breeding historyCongenic
References
  • Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.;Bazigou Eleni, Lyons Oliver T A, Smith Alberto, Venn Graham E, Cope Celia, Brown Nigel A, Makinen Taija, ;2011;The Journal of clinical investigation;121;2984-92; 21765212
  • MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell-Suppressive Functions.;Gkountidi Anastasia O, Garnier Laure, Dubrot Juan, Angelillo Julien, Harlé Guillaume, Brighouse Dale, Wrobel Ludovic J, Pick Robert, Scheiermann Christoph, Swartz Melody A, Hugues Stéphanie, ;2021;Cancer immunology research;9;748-764; 33952631
  • Absence of MHC-II expression by lymph node stromal cells results in autoimmunity.;Dubrot Juan, Duraes Fernanda V, Harlé Guillaume, Schlaeppi Anjalie, Brighouse Dale, Madelon Natacha, Göpfert Christine, Stokar-Regenscheit Nadine, Acha-Orbea Hans, Reith Walter, Gannagé Monique, Hugues Stephanie, ;2018;Life science alliance;1;e201800164; 30584641
  • The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling.;Carlantoni Claudia, Liekfeld Leon M H, Hemkemeyer Sandra A, Schreier Danny, Saygi Ceren, Kurelic Roberta, Cardarelli Silvia, Kalucka Joanna, Schulte Christian, Beerens Manu, Mailer Reiner K, Schäffer Tilman E, Naro Fabio, Pellegrini Manuela, Nikolaev Viacheslav O, Renné Thomas, Frye Maike, ;2024;Developmental cell;59;308-325.e11; 38159569
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

  • Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.;Bazigou Eleni, Lyons Oliver T A, Smith Alberto, Venn Graham E, Cope Celia, Brown Nigel A, Makinen Taija, ;2011;The Journal of clinical investigation;121;2984-92; 21765212
  • MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell-Suppressive Functions.;Gkountidi Anastasia O, Garnier Laure, Dubrot Juan, Angelillo Julien, Harlé Guillaume, Brighouse Dale, Wrobel Ludovic J, Pick Robert, Scheiermann Christoph, Swartz Melody A, Hugues Stéphanie, ;2021;Cancer immunology research;9;748-764; 33952631
  • Absence of MHC-II expression by lymph node stromal cells results in autoimmunity.;Dubrot Juan, Duraes Fernanda V, Harlé Guillaume, Schlaeppi Anjalie, Brighouse Dale, Madelon Natacha, Göpfert Christine, Stokar-Regenscheit Nadine, Acha-Orbea Hans, Reith Walter, Gannagé Monique, Hugues Stephanie, ;2018;Life science alliance;1;e201800164; 30584641
  • The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling.;Carlantoni Claudia, Liekfeld Leon M H, Hemkemeyer Sandra A, Schreier Danny, Saygi Ceren, Kurelic Roberta, Cardarelli Silvia, Kalucka Joanna, Schulte Christian, Beerens Manu, Mailer Reiner K, Schäffer Tilman E, Naro Fabio, Pellegrini Manuela, Nikolaev Viacheslav O, Renné Thomas, Frye Maike, ;2024;Developmental cell;59;308-325.e11; 38159569

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).