C.Cg-Tg(IGHMdeltaV)6Corc/Cnrm
| Status | Available to order |
| EMMA ID | EM:01369 |
| Citation information | RRID:IMSR_EM:01369 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C.Cg-Tg(IGHMdeltaV)6Corc/Cnrm |
| Alternative name | delta-V mu 6 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(IGHMdeltaV)6Corc |
| Gene/Transgene symbol | Tg(IGHMdeltaV)6Corc |
Information from provider
| Provider | Daniel Corcos |
| Provider affiliation | ER70 CNRS et Unite 125 Inserm |
| Genetic information | The delta-V mu construct encodes a human immunoglobulin mu heavy chain with a total deletion of the VDJ exon. |
| Phenotypic information | Expression of the delta-V mu construct in conventional B cells leads to a quasi-total allelic exclusion of endogenous immunoglobulin genes. As a consequence, B cells express a truncated B-cell receptor devoid of antigen binding domain. The delta-V mu protein allows pre-B cell development in the absence of surrogate light chains. |
| Breeding history | Backcrossed to BALB/c for at least 12 generations. Currently bred as homozygous. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Allelic exclusion in transgenic mice expressing a heavy chain disease-like human mu protein.;Corcos D, Iglesias A, Dunda O, Bucchini D, Jami J, ;1991;European journal of immunology;21;2711-6; 1936120
- Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein.;Corcos D, Dunda O, Butor C, Cesbron J Y, Lorès P, Bucchini D, Jami J, ;1995;Current biology : CB;5;1140-8; 8548286
- Expression of a V region-less B cell receptor confers a tolerance-like phenotype on transgenic B cells.;Corcos D, Grandien A, Vazquez A, Dunda O, Lorès P, Bucchini D, ;2001;Journal of immunology (Baltimore, Md. : 1950);166;3083-9; 11207259
- The role of the B cell receptor V region in peripheral B cell survival.;Rosado M M, Freitas A A, ;1998;European journal of immunology;28;2685-93; 9754556