B6;CD1-Ip6k1tm1Cgen Ip6k2tm1Cgen/Orl
| Status | Available to order |
| EMMA ID | EM:13688 |
| International strain name | B6;CD1-Ip6k1tm1Cgen Ip6k2tm1Cgen/Orl |
| Alternative name | f-Ip6k1/Ip6k2 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Ip6k1tm1, Ip6k2tm1 |
| Gene/Transgene symbol | Ip6k1, Ip6k2 |
Information from provider
| Provider | Carsten A Wagner |
| Provider affiliation | Physiology, University Zurich |
| Genetic information | LoxP sites inserted into the genes encoding for the inositol hexakisphosphate kinases Ip6k1 and Ip6k2. The targeted exons were exon 3 and exons 2-3, respectively. |
| Phenotypic information | Homozygous:Mice have no phenotype, as loxP sites were introduced in intronic sequencesHeterozygous:Mice have no phenotype, as loxP sites were introduced in intronic sequences |
| Breeding history | Homozygous mice breed normally |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous strain EM:13688 background: C57BL/6 or mixed C57BL/6 x CD1 |
Literature references
- The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.;Haykir Betül, Moser Seraina Olivia, Pastor-Arroyo Eva Maria, Schnitzbauer Udo, Radvanyi Zsuzsa, Prucker Isabel, Qiu Danye, Fiedler Dorothea, Saiardi Adolfo, Jessen Henning J, Hernando Nati, Wagner Carsten A, ;2024;Journal of the American Society of Nephrology : JASN;35;441-455; 38317282