B6;CD1-Ip6k1tm1Cgen Ip6k2tm1Cgen/Orl
| Status | Available to order |
| EMMA ID | EM:13688 |
| Citation information | RRID:IMSR_EM:13688 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;CD1-Ip6k1tm1Cgen Ip6k2tm1Cgen/Orl |
| Alternative name | f-Ip6k1/Ip6k2 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Ip6k1tm1, Ip6k2tm1 |
| Gene/Transgene symbol | Ip6k1, Ip6k2 |
Information from provider
| Provider | Carsten A Wagner |
| Provider affiliation | Physiology, University Zurich |
| Genetic information | LoxP sites inserted into the genes encoding for the inositol hexakisphosphate kinases Ip6k1 and Ip6k2. The targeted exons were exon 3 and exons 2-3, respectively. |
| Phenotypic information | Homozygous:Mice have no phenotype, as loxP sites were introduced in intronic sequencesHeterozygous:Mice have no phenotype, as loxP sites were introduced in intronic sequences |
| Breeding history | Homozygous mice breed normally |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous strain EM:13688 background: C57BL/6 or mixed C57BL/6 x CD1 males |
Literature references
- The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.;Haykir Betül, Moser Seraina Olivia, Pastor-Arroyo Eva Maria, Schnitzbauer Udo, Radvanyi Zsuzsa, Prucker Isabel, Qiu Danye, Fiedler Dorothea, Saiardi Adolfo, Jessen Henning J, Hernando Nati, Wagner Carsten A, ;2024;Journal of the American Society of Nephrology : JASN;35;441-455; 38317282