B6Dnk;B6Brd;B6N-Tyrc-Brd Peds1tm1a(KOMP)Wtsi/WtsiOrl

Status

Available to order

EMMA IDEM:13673
International strain nameB6Dnk;B6Brd;B6N-Tyrc-Brd Peds1tm1a(KOMP)Wtsi/WtsiOrl
Alternative nameEPD0026_4_C08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolPeds1tm1a(KOMP)Wtsi
Gene/Transgene symbolPeds1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0026_4_C08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous B6Brd;B6Dnk;B6N-Tyr

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased bone mineral density / IMPC
  • decreased circulating calcium level / IMPC
  • decreased hematocrit / IMPC
  • abnormal retina morphology / IMPC
  • abnormal eye morphology / IMPC
  • increased mean corpuscular volume / IMPC
  • increased mean platelet volume / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • decreased lean body mass / IMPC
  • abnormal retina pigmentation / IMPC
  • absent pinna reflex / IMPC
  • decreased circulating fructosamine level / IMPC
  • abnormal incisor color / IMPC
IMPC phenotypes (gene matching)
  • abnormal retina morphology / IMPC
  • increased mean platelet volume / IMPC
  • decreased lean body mass / IMPC
  • decreased circulating calcium level / IMPC
  • decreased erythrocyte cell number / IMPC
  • abnormal incisor color / IMPC
  • decreased circulating fructosamine level / IMPC
  • decreased hemoglobin content / IMPC
  • abnormal retina pigmentation / IMPC
  • decreased hematocrit / IMPC
  • decreased bone mineral density / IMPC
  • absent pinna reflex / IMPC
  • increased mean corpuscular volume / IMPC
  • abnormal eye morphology / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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