C57BL/6N-Mettm2(MET*)Tcre/Cnrm

Status

Available to order

EMMA IDEM:13663
Citation informationRRID:IMSR_EM:13663 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Mettm2(MET*)Tcre/Cnrm
Alternative nameEx14Del-ki
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolMettm2(MET*)Tcre
Gene/Transgene symbolMet

Information from provider

ProviderPAOLO COMOGLIO
Provider affiliationIFOM - Istituto FIRC di Oncologia Molecolare
Additional ownerTiziana Crepaldi, Ph.D., Department of Oncology, University of Turin, Candiolo Cancer Institute, Candiolo (Torino) ITALY
Genetic informationEx14Del-ki mice harbour the "humanized" knock-in mutation of the human MET allele without exon 14, which replaces the mouse Met gene. The coding region of exon 3 plus partial intron 3 was replaced with the mutant human MET CDS without exon 14 (NM_000245.4; 4032 bp). C57BL/6N ES cells were used for gene targeting.
Phenotypic informationHomozygous:
not known

Heterozygous:
Mice heterozygous for the Ex14Del-ki allele are viable and fertile.
Breeding historyThe Ex14Del-ki mice were bred with C57BL/6N to generate the heterozygous mice.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • hydronephrosis / MGI
  • abnormal forelimb morphology / MGI
  • abnormal liver development / MGI
  • small liver / MGI
  • enlarged liver sinusoidal spaces / MGI
  • abnormal myogenesis / MGI
  • abnormal muscle development / MGI
  • thin diaphragm muscle / MGI
  • abnormal tongue morphology / MGI
  • small cerebellum / MGI
  • abnormal motor neuron innervation pattern / MGI
  • abnormal somatic motor system morphology / MGI
  • impaired coordination / MGI
  • decreased embryo size / MGI
  • abnormal placenta development / MGI
  • decreased trophoblast giant cell number / MGI
  • abnormal placenta labyrinth morphology / MGI
  • postnatal growth retardation / MGI
  • increased mammary adenocarcinoma incidence / MGI
  • respiratory failure / MGI
  • neoplasm / MGI
  • increased tumor incidence / MGI
  • increased sarcoma incidence / MGI
  • increased carcinoma incidence / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • abnormal diaphragm morphology / MGI
  • glomerulonephritis / MGI
  • no phenotypic analysis / MGI
  • abnormal muscle precursor cell migration / MGI
  • hypaxial muscle hypoplasia / MGI
  • decreased liver weight / MGI
  • nervous system phenotype / MGI
  • abnormal axon extension / MGI
  • increased hemangiosarcoma incidence / MGI
  • diaphragmatic hernia / MGI
  • chromosome breakage / MGI
  • abnormal tongue muscle morphology / MGI
  • abnormal fetal growth/weight/body size / MGI
  • decreased fetal size / MGI
  • increased squamous cell carcinoma incidence / MGI
  • small placenta / MGI
  • pale placenta / MGI
  • abnormal neuron physiology / MGI
  • decreased skeletal muscle mass / MGI
  • absent skeletal muscle / MGI
  • muscle phenotype / MGI
  • embryo phenotype / MGI
  • abnormal liver parenchyma morphology / MGI
  • increased histiocytic sarcoma incidence / MGI
  • paraparesis / MGI
  • reduced cerebellar foliation / MGI
  • decreased tongue size / MGI
  • abnormal neuron differentiation / MGI
  • decreased lung tumor incidence / MGI
  • increased mammary gland tumor incidence / MGI
  • mortality/aging / MGI
  • neonatal lethality, complete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • absent diaphragm / MGI
  • increased myoepithelioma incidence / MGI
  • abnormal diaphragm development / MGI
  • increased lymphoma incidence / MGI
  • abnormal intrinsic tongue muscle morphology / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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