B6NCrl;B6N-Atm1Brd Ddr1tm1c(EUCOMM)Hmgu/Orl

Status

Available to order

EMMA IDEM:13657
International strain nameB6NCrl;B6N-Atm1Brd Ddr1tm1c(EUCOMM)Hmgu/Orl
Alternative nameB6NCrl;B6N-A tm1Brd Ddr1 tm1c(EUCOMM)Hmgu /Orl
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolDdr1tm1c(EUCOMM)Hmgu
Gene/Transgene symbolDdr1

Information from provider

ProviderCécile FREMOND
Provider affiliationCNRS-TAAM
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0812_6_B12. For further details on the construction of this clone see the relevant page (https://www.mousephenotype.org/data/alleles/MGI:99216/tm1a(EUCOMM)Hmgu) at the IMPC portal. The tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele.
Phenotypic informationHomozygous:
Homozygous mice have not been generated

Heterozygous:
Null
Breeding historyRederived tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NCrl

Disease and phenotype information

IMPC phenotypes (gene matching)
  • hyperactivity / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal cranium morphology / MGI
  • abnormal mammary gland development / MGI
  • decreased anxiety-related response / MGI
  • hyperactivity / MGI
  • failure of embryo implantation / MGI
  • postnatal growth retardation / MGI
  • abnormal lactation / MGI
  • abnormal outer ear morphology / MGI
  • abnormal bone mineralization / MGI
  • increased urine protein level / MGI
  • renal/urinary system phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • abnormal podocyte slit diaphragm morphology / MGI
  • abnormal mammary gland duct morphology / MGI
  • abnormal renal tubule epithelium morphology / MGI
  • increased mammary gland epithelial cell proliferation / MGI
  • increased renal glomerulus basement membrane thickness / MGI
  • erythrocyturia / MGI
  • abnormal aorta collagen fibril morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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