C57BL/6NCrl-Fancd2^{em1(IMPC)Hmgu}/Ieg

Status	Available to order
EMMA ID	EM:13625
Citation information	RRID:IMSR_EM:13625 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NCrl-Fancd2^{em1(IMPC)Hmgu}/Ieg
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Fancd2^{em1(IMPC)Hmgu}
Gene/Transgene symbol	Fancd2

Information from provider

Provider	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliation	Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archiving	heterozygous C57BL/6N males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Fanconi anemia / Orphanet_84

IMPC phenotypes (allele matching)

persistence of hyaloid vascular system / IMPC
small kidney / IMPC
increased circulating iron level / IMPC
abnormal retina blood vessel morphology / IMPC
preweaning lethality, complete penetrance / IMPC
process of degenerative change / IMPC
granulation tissue / IMPC
inflammation / IMPC
developmental and structural abnormality / IMPC
hydronephrosis / IMPC

IMPC phenotypes (gene matching)

granulation tissue / IMPC
process of degenerative change / IMPC
abnormal retina blood vessel morphology / IMPC
preweaning lethality, complete penetrance / IMPC
persistence of hyaloid vascular system / IMPC
increased circulating iron level / IMPC
developmental and structural abnormality / IMPC
inflammation / IMPC
hydronephrosis / IMPC
small kidney / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6NCrl-Fancd2em1(IMPC)Hmgu/Ieg