MGI phenotypes (gene matching)
B6.Cg-Anxa10tm1.1(cre/ERT2)Dstan/Ieg
| Status | Available to order |
| EMMA ID | EM:13609 |
| Citation information | RRID:IMSR_EM:13609 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Anxa10tm1.1(cre/ERT2)Dstan/Ieg |
| Alternative name | Anxa10-CreERT2 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Anxa10tm1.1(cre/ERT2)Dstan |
| Gene/Transgene symbol | Anxa10 |
Information from provider
| Provider | Daniel Stange |
| Provider affiliation | Universitätsklinikum Carl Gustav Carus Dresden |
| Genetic information | The Anxa10-CreERT2 transgenic mice express a tamoxifen inducible Cre recombinase driven by the annexin A10 (Anxa10) promoter. Mice were generated via homologous recombination by inserting a CreERT2 cassette with a Neomycin resistance cassette flanked by FRT sites after the last exon (12) in the Anxa10 locus. Anxa10 is a stomach specific protein which is expressed in all cells of the stomach epithelium. |
| Phenotypic information | Homozygous:Homozygous Anxa10-CreERT2 mice are phenotypically unaffected.Heterozygous:Heterozygous Anxa10-CreERT2 mice are phenotypically as wild-type mice. |
| Breeding history | The mice were generated with Bruce4 ES cells that have a C57BL/6-Thy1.1 background. The ES cells were transplanted in mice with C57BL/6J background. Offsprings were bred to FlpO mice with C57BL/6J background to remove the neo cassette. From then on mice were crossed as sib-matings for 16 generations (F16). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
Literature references
- Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations.;Seidlitz Therese, Chen Yi-Ting, Uhlemann Heike, Schölch Sebastian, Kochall Susan, Merker Sebastian R, Klimova Anna, Hennig Alexander, Schweitzer Christine, Pape Kristin, Baretton Gustavo B, Welsch Thilo, Aust Daniela E, Weitz Jürgen, Koo Bon-Kyoung, Stange Daniel E, ;2019;Gastroenterology;157;1599-1614.e2; 31585123