STOCK Ctslnkt/Ieg

Status

Available to order

EMMA IDEM:00136
International strain nameSTOCK Ctslnkt/Ieg
Alternative namenkt, nackt
Strain typeInduced Mutant Strains : Radiation-induced
Allele/Transgene symbolCtslnkt
Gene/Transgene symbolCtsl

Information from provider

ProviderDietmar Schlote
Provider affiliationMartin-Luther University, Halle/Wittenberg
Phenotypic informationhair loss, CD4 deficiency
References
  • Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency.;Benavides F, Giordano M, Fiette L, Bueno Brunialti A L, Martin Palenzuela N, Vanzulli S, Baldi P, Schmidt R, Dosne Pasqualini C, Guénet J, ;1999;Immunogenetics;49;413-9; 10199917

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal coat/ hair morphology / MGI
  • alopecia / MGI
  • sparse hair / MGI
  • delayed hair appearance / MGI
  • enlarged sebaceous gland / MGI
  • enlarged lymph nodes / MGI
  • dermatitis / MGI
  • skin lesions / MGI
  • epidermal hyperplasia / MGI
  • thick dermal layer / MGI
  • decreased body size / MGI
  • corneal opacity / MGI
  • excessive scratching / MGI
  • acanthosis / MGI
  • abnormal hair growth / MGI
  • abnormal hair follicle development / MGI
  • abnormal hair shaft morphology / MGI
  • abnormal external auditory canal morphology / MGI
  • abnormal hair cycle catagen phase / MGI
  • orthokeratosis / MGI
  • integument phenotype / MGI
  • dental pulp necrosis / MGI
  • periodontal ligament necrosis / MGI
  • abnormal leukocyte cell number / MGI
  • abnormal thymus morphology / MGI
  • thick epidermis / MGI
  • abnormal lymph node morphology / MGI
  • abnormal lymph node cortex morphology / MGI
  • abnormal thymus lobule morphology / MGI
  • abnormal immune system organ morphology / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • abnormal thymus corticomedullary boundary morphology / MGI
  • dilated lymph node medullary sinus / MGI
  • enlarged thymus cortex / MGI
  • abnormal hair follicle morphology / MGI
  • postnatal growth retardation / MGI
  • increased inflammatory response / MGI
  • liver inflammation / MGI
  • thymus atrophy / MGI
  • lymph node inflammation / MGI
  • cachexia / MGI
  • lymph node hyperplasia / MGI
  • hypergranulosis / MGI
  • rough coat / MGI
  • postnatal lethality, incomplete penetrance / MGI
MGI phenotypes (gene matching)
  • abnormal trabecular bone morphology / MGI
  • abnormal cartilage morphology / MGI
  • abnormal leukocyte cell number / MGI
  • enlarged heart / MGI
  • abnormal myocardial fiber morphology / MGI
  • abnormal coat/ hair morphology / MGI
  • folliculitis / MGI
  • abnormal hair follicle morphology / MGI
  • underdeveloped hair follicles / MGI
  • abnormal hair follicle orientation / MGI
  • alopecia / MGI
  • sparse hair / MGI
  • short hair / MGI
  • delayed hair appearance / MGI
  • abnormal hair cycle / MGI
  • amyloidosis / MGI
  • enlarged sebaceous gland / MGI
  • abnormal thyroid gland morphology / MGI
  • enlarged lymph nodes / MGI
  • abnormal thymus morphology / MGI
  • abnormal spermatogenesis / MGI
  • scaly skin / MGI
  • dermatitis / MGI
  • shiny skin / MGI
  • thick skin / MGI
  • skin lesions / MGI
  • thick epidermis / MGI
  • epidermal hyperplasia / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • hyperkeratosis / MGI
  • thick dermal layer / MGI
  • decreased body size / MGI
  • short vibrissae / MGI
  • sparse vibrissae / MGI
  • absent vibrissae / MGI
  • corneal opacity / MGI
  • excessive scratching / MGI
  • abnormal coat appearance / MGI
  • abnormal osteoclast physiology / MGI
  • abnormal cardiovascular system physiology / MGI
  • hyperglycemia / MGI
  • abnormal visceral yolk sac morphology / MGI
  • postnatal growth retardation / MGI
  • increased inflammatory response / MGI
  • liver inflammation / MGI
  • salivary gland inflammation / MGI
  • acanthosis / MGI
  • abnormal hair growth / MGI
  • abnormal seminiferous tubule morphology / MGI
  • abnormal lymph node morphology / MGI
  • abnormal lymph node cortex morphology / MGI
  • abnormal thymus lobule morphology / MGI
  • granulomatous inflammation / MGI
  • heart left ventricle hypertrophy / MGI
  • increased heart rate / MGI
  • abnormal immune system organ morphology / MGI
  • dilated cardiomyopathy / MGI
  • increased heart weight / MGI
  • abnormal keratinocyte physiology / MGI
  • thymus atrophy / MGI
  • abnormal hair follicle development / MGI
  • abnormal hair shaft morphology / MGI
  • greasy coat / MGI
  • lymph node inflammation / MGI
  • insulitis / MGI
  • abnormal heartbeat / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased testis weight / MGI
  • increased regulatory T cell number / MGI
  • decreased osteoclast cell number / MGI
  • abnormal lysosome morphology / MGI
  • decreased cardiac muscle contractility / MGI
  • cachexia / MGI
  • abnormal myocardium layer morphology / MGI
  • renal/urinary system phenotype / MGI
  • abnormal thyroid hormone level / MGI
  • decreased thyroxine level / MGI
  • decreased ventricle muscle contractility / MGI
  • cardiac interstitial fibrosis / MGI
  • abnormal external auditory canal morphology / MGI
  • mitral valve regurgitation / MGI
  • aortic valve regurgitation / MGI
  • decreased long bone epiphyseal plate size / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • lymph node hyperplasia / MGI
  • enlarged heart left atrium / MGI
  • abnormal hair cycle catagen phase / MGI
  • abnormal thymus corticomedullary boundary morphology / MGI
  • increased keratinocyte proliferation / MGI
  • hypergranulosis / MGI
  • orthokeratosis / MGI
  • rough coat / MGI
  • focal dorsal hair loss / MGI
  • abnormal T wave / MGI
  • abnormal heart electrocardiography waveform feature / MGI
  • atrioventricular block / MGI
  • hair follicle outer root sheath hyperplasia / MGI
  • integument phenotype / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • abnormal visceral endoderm morphology / MGI
  • dilated lymph node medullary sinus / MGI
  • abnormal R wave / MGI
  • abnormal heart echocardiography feature / MGI
  • dental pulp necrosis / MGI
  • enlarged thymus cortex / MGI
  • periodontal ligament necrosis / MGI
  • dilated piliary canal / MGI

Literature references

  • Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency.;Benavides F, Giordano M, Fiette L, Bueno Brunialti A L, Martin Palenzuela N, Vanzulli S, Baldi P, Schmidt R, Dosne Pasqualini C, Guénet J, ;1999;Immunogenetics;49;413-9; 10199917

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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