C57BL/6NCrl-Guloem1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:13575
International strain nameC57BL/6NCrl-Guloem1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolGuloem1(IMPC)Ccpcz
Gene/Transgene symbolGulo

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal heart morphology / IMPC
  • enlarged heart / IMPC
  • abnormal spleen morphology / IMPC
  • enlarged spleen / IMPC
  • anophthalmia / IMPC
  • hyperactivity / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • abnormal eye morphology / IMPC
  • decreased lean body mass / IMPC
  • decreased spleen weight / IMPC
  • increased circulating cholesterol level / IMPC
  • abnormal optic disk morphology / IMPC
IMPC phenotypes (gene matching)
  • enlarged heart / IMPC
  • abnormal eye morphology / IMPC
  • abnormal spleen morphology / IMPC
  • anophthalmia / IMPC
  • abnormal heart morphology / IMPC
  • abnormal optic disk morphology / IMPC
  • decreased spleen weight / IMPC
  • hyperactivity / IMPC
  • decreased lean body mass / IMPC
  • enlarged spleen / IMPC
  • increased circulating cholesterol level / IMPC
  • increased circulating HDL cholesterol level / IMPC
MGI phenotypes (gene matching)
  • fragile skeleton / MGI
  • decreased bone mineral density / MGI
  • abnormal trabecular bone morphology / MGI
  • decreased compact bone thickness / MGI
  • abnormal vertebral body morphology / MGI
  • decreased chondrocyte number / MGI
  • decreased circulating HDL cholesterol level / MGI
  • decreased circulating calcium level / MGI
  • decreased circulating phosphate level / MGI
  • decreased hematocrit / MGI
  • gastrointestinal hemorrhage / MGI
  • small spleen / MGI
  • small thymus / MGI
  • hindlimb paralysis / MGI
  • weight loss / MGI
  • decreased body size / MGI
  • cataract / MGI
  • abnormal retina morphology / MGI
  • hypoactivity / MGI
  • abnormal gait / MGI
  • disheveled coat / MGI
  • abnormal skeleton physiology / MGI
  • anemia / MGI
  • postnatal growth retardation / MGI
  • hemorrhage / MGI
  • premature death / MGI
  • decreased erythrocyte cell number / MGI
  • abnormal bone mineralization / MGI
  • decreased circulating alkaline phosphatase level / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • enlarged kidney / MGI
  • increased vascular permeability / MGI
  • rickets / MGI
  • decreased circulating insulin-like growth factor I level / MGI
  • increased circulating cholesterol level / MGI
  • increased brain size / MGI
  • liver/biliary system phenotype / MGI
  • cardiovascular system phenotype / MGI
  • reproductive system phenotype / MGI
  • decreased mean corpuscular hemoglobin / MGI
  • abnormal osteoclast differentiation / MGI
  • slow postnatal weight gain / MGI
  • abnormal aorta elastic tissue morphology / MGI
  • abnormal aorta endothelium morphology / MGI
  • abnormal aorta smooth muscle morphology / MGI
  • abnormal vitamin C level / MGI
  • femur fracture / MGI
  • rachitic rosary / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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