- abnormal heart morphology / IMPC
- enlarged heart / IMPC
- abnormal spleen morphology / IMPC
- enlarged spleen / IMPC
- anophthalmia / IMPC
- hyperactivity / IMPC
- increased circulating HDL cholesterol level / IMPC
- abnormal eye morphology / IMPC
- decreased lean body mass / IMPC
- decreased spleen weight / IMPC
- increased circulating cholesterol level / IMPC
- abnormal optic disk morphology / IMPC
C57BL/6NCrl-Guloem1(IMPC)Ccpcz/Ph
Status | Under development - register interest |
EMMA ID | EM:13575 |
Citation information | RRID:IMSR_EM:13575 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6NCrl-Guloem1(IMPC)Ccpcz/Ph |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Guloem1(IMPC)Ccpcz |
Gene/Transgene symbol | Gulo |
Information from provider
Provider | Institute of Molecular Genetics |
Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
IMPC phenotypes (allele matching)
IMPC phenotypes (gene matching)
- enlarged heart / IMPC
- abnormal eye morphology / IMPC
- abnormal spleen morphology / IMPC
- anophthalmia / IMPC
- abnormal heart morphology / IMPC
- abnormal optic disk morphology / IMPC
- decreased spleen weight / IMPC
- hyperactivity / IMPC
- decreased lean body mass / IMPC
- enlarged spleen / IMPC
- increased circulating cholesterol level / IMPC
- increased circulating HDL cholesterol level / IMPC
MGI phenotypes (gene matching)
- fragile skeleton / MGI
- decreased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- decreased compact bone thickness / MGI
- abnormal vertebral body morphology / MGI
- decreased chondrocyte number / MGI
- decreased circulating HDL cholesterol level / MGI
- decreased circulating calcium level / MGI
- decreased circulating phosphate level / MGI
- decreased hematocrit / MGI
- gastrointestinal hemorrhage / MGI
- small spleen / MGI
- small thymus / MGI
- hindlimb paralysis / MGI
- weight loss / MGI
- decreased body size / MGI
- cataract / MGI
- abnormal retina morphology / MGI
- hypoactivity / MGI
- abnormal gait / MGI
- disheveled coat / MGI
- abnormal skeleton physiology / MGI
- anemia / MGI
- postnatal growth retardation / MGI
- hemorrhage / MGI
- premature death / MGI
- decreased erythrocyte cell number / MGI
- abnormal bone mineralization / MGI
- decreased circulating alkaline phosphatase level / MGI
- abnormal long bone epiphyseal plate morphology / MGI
- enlarged kidney / MGI
- increased vascular permeability / MGI
- rickets / MGI
- decreased circulating insulin-like growth factor I level / MGI
- increased circulating cholesterol level / MGI
- increased brain size / MGI
- liver/biliary system phenotype / MGI
- cardiovascular system phenotype / MGI
- reproductive system phenotype / MGI
- decreased mean corpuscular hemoglobin / MGI
- abnormal osteoclast differentiation / MGI
- slow postnatal weight gain / MGI
- abnormal aorta elastic tissue morphology / MGI
- abnormal aorta endothelium morphology / MGI
- abnormal aorta smooth muscle morphology / MGI
- abnormal vitamin C level / MGI
- femur fracture / MGI
- rachitic rosary / MGI
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