B10.Cg-Ncf1m1J H2q/Kctt

Status

Available to order

EMMA IDEM:01353
Citation informationRRID:IMSR_EM:01353 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB10.Cg-Ncf1m1J H2q/Kctt
Alternative nameRHo-7
Strain typeSpontaneous
Allele/Transgene symbolNcf1m1J, H2q
Gene/Transgene symbolNcf1, H2

Information from provider

ProviderRikard Holmdahl
Provider affiliationLund University, CMB, Section for medical inflammation reseach
Genetic informationThe strain lacks expression of Ncf1 when homozygous for the mutation. The strain is based on The Jackson Laboratory's strain B6.Cg-Dock7m +/+ Leprdb/J (JAX stock ID 000697). However, this strain lacks the Lepr mutation, and basically only the Ncf1 gene remains from the original strain (minimal fragment). It is also backcrossed to C57BL/10.Q to a pure background (speed congenics).
Phenotypic informationNone.
Breeding historyBackcrossed to B10.Q for more than 10 generations by speed congenics.
References
  • Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.;Hultqvist Malin, Olofsson Peter, Holmberg Jens, Bäckström B Thomas, Tordsson Jesper, Holmdahl Rikard, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;12646-51; 15310853

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden
Stage of embryos2-cell

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal heart morphology / IMPC
  • abnormal behavior / IMPC
  • decreased thigmotaxis / IMPC
  • enlarged spleen / IMPC
  • abnormal spleen morphology / IMPC
  • abnormal lymph node morphology / IMPC
  • enlarged lymph nodes / IMPC
  • abnormal eye morphology / IMPC
  • hyperplasia / IMPC
  • decreased anxiety-related response / IMPC
  • small kidney / IMPC
  • abnormal kidney morphology / IMPC
  • increased heart atrium size / IMPC
  • abnormal skin morphology / IMPC
  • abnormal lung morphology / IMPC
  • single kidney / IMPC
  • enlarged kidney / IMPC
  • decreased locomotor activity / IMPC
MGI phenotypes (allele matching)
  • decreased susceptibility to viral infection / MGI
  • abnormal macrophage physiology / MGI
  • impaired granulocyte bactericidal activity / MGI
  • oxidative stress / MGI
MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • abnormal liver physiology / MGI
  • abnormal T cell differentiation / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgM level / MGI
  • abnormal cytokine secretion / MGI
  • thyroid inflammation / MGI
  • increased autoantibody level / MGI
  • insulitis / MGI
  • increased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to parasitic infection / MGI
  • immune system phenotype / MGI
  • periinsulitis / MGI
  • abnormal T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • abnormal angiogenesis / MGI
  • abnormal heart morphology / MGI
  • altered response to myocardial infarction / MGI
  • abnormal lung morphology / MGI
  • skin lesions / MGI
  • abnormal spatial learning / MGI
  • reduced long term potentiation / MGI
  • abnormal cardiovascular system physiology / MGI
  • cardiac hypertrophy / MGI
  • abnormal postnatal growth / MGI
  • abnormal inflammatory response / MGI
  • abnormal respiratory system physiology / MGI
  • abnormal tracheal smooth muscle morphology / MGI
  • increased susceptibility to infection / MGI
  • decreased susceptibility to viral infection / MGI
  • abnormal macrophage physiology / MGI
  • abnormal neutrophil physiology / MGI
  • granulomatous inflammation / MGI
  • dilated heart left ventricle / MGI
  • increased systemic arterial blood pressure / MGI
  • abnormal bile duct morphology / MGI
  • abnormal cardiac muscle contractility / MGI
  • enhanced long term potentiation / MGI
  • decreased vasoconstriction / MGI
  • increased angiotensin I-converting enzyme activity / MGI
  • abnormal locomotor activation / MGI
  • liver abscess / MGI
  • increased circulating renin level / MGI
  • abnormal intestinal goblet cell morphology / MGI
  • oxidative stress / MGI
  • abnormal vascular endothelial cell physiology / MGI
  • abnormal vascular wound healing / MGI
  • abnormal response to infection / MGI
  • impaired granulocyte bactericidal activity / MGI
  • increased acute inflammation / MGI
  • immune system phenotype / MGI
  • abnormal vascular smooth muscle physiology / MGI
  • impaired cued conditioning behavior / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • increased lung compliance / MGI
  • decreased airway resistance / MGI

Literature references

  • Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.;Hultqvist Malin, Olofsson Peter, Holmberg Jens, Bäckström B Thomas, Tordsson Jesper, Holmdahl Rikard, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;12646-51; 15310853

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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Practical information

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