C57BL/6N-Ppm1dtm1.2(IMPC)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:13529
Citation informationRRID:IMSR_EM:13529 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Ppm1dtm1.2(IMPC)Wtsi/WtsiH
Alternative namePpm1dtm1.2(IMPC)Wtsi (TBXX)
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolPpm1dtm1.2(IMPC)Wtsi 
Gene/Transgene symbolPpm1d

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationPpm1dtm1.2(IMPC)Wtsi. KI replacing exon 6 with a human codon optimised exon 6 followed by a stop cassette and human codon optimised point mutated exon 6 resulting in deletion of T Chr 11:85345824 cause a premature stop codon at L476stop. Post flp deletion of selectable marker
Phenotypic informationHomozygous:
data not available

Heterozygous:
data not available
Breeding historyChimeras crossed with C57BL/6N then hets crossed with flp on C57BL/6N and crossed with C57BL/6N, then intercrossed
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (gene matching)
  • lymphoid hyperplasia / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • small thymus / MGI
  • small testis / MGI
  • seminiferous tubule degeneration / MGI
  • skin lesions / MGI
  • decreased body size / MGI
  • male infertility / MGI
  • premature death / MGI
  • increased susceptibility to viral infection / MGI
  • chronic inflammation / MGI
  • abnormal epididymis morphology / MGI
  • oligozoospermia / MGI
  • decreased B cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • impaired glucose tolerance / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • myeloid hyperplasia / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • decreased pancreatic beta cell proliferation / MGI

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Practical information

Genotyping protocol

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