C57BL/6N-Kdm5b^{em2(IMPC)Wtsi}/WtsiH

Status	Available to order
EMMA ID	EM:13527
International strain name	C57BL/6N-Kdm5b^{em2(IMPC)Wtsi}/WtsiH
Alternative name	Kdm5bem2(IMPC)Wtsi (VAAE)
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Kdm5b^{em2(IMPC)Wtsi}
Gene/Transgene symbol	Kdm5b

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	Kdm5bem2(IMPC)Wtsi. Inverted exon KI, reverted to WT via loxP71/loxP66 inversion
Phenotypic information	Homozygous: data not available Heterozygous: data not available
Breeding history	Mosaic crossed with C57BL/6N then intercrossed
References	None available
Homozygous fertile	not known
Homozygous viable	yes
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Autosomal recessive non-syndromic intellectual disability / Orphanet_88616

IMPC phenotypes (gene matching)

absent pinna reflex / IMPC
decreased body length / IMPC
preweaning lethality, incomplete penetrance / IMPC

MGI phenotypes (gene matching)

abnormal mammary gland development / MGI
abnormal branching of the mammary ductal tree / MGI
reduced female fertility / MGI
female infertility / MGI
premature death / MGI
no phenotypic analysis / MGI
decreased uterus weight / MGI
decreased circulating estradiol level / MGI
slow postnatal weight gain / MGI
mortality/aging / MGI
neonatal lethality, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6N-Kdm5bem2(IMPC)Wtsi/WtsiH