C57BL/6NCrl-Tanc2em1(IMPC)Hmgu/Ieg

Status

Available to order

EMMA IDEM:13497
International strain nameC57BL/6NCrl-Tanc2em1(IMPC)Hmgu/Ieg
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolTanc2em1(IMPC)Hmgu
Gene/Transgene symbolTanc2

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.;Garrett Lillian, Da Silva-Buttkus Patricia, Rathkolb Birgit, Gerlini Raffaele, Becker Lore, Sanz-Moreno Adrian, Seisenberger Claudia, Zimprich Annemarie, Aguilar-Pimentel Antonio, Amarie Oana V, Cho Yi-Li, Kraiger Markus, Spielmann Nadine, Calzada-Wack Julia, Marschall Susan, Busch Dirk, Schmitt-Weber Carsten, Wolf Eckhard, Wurst Wolfgang, Fuchs Helmut, Gailus-Durner Valerie, Hölter Sabine M, Hrabě de Angelis Martin, ;2022;Disease models & mechanisms;15;; 34964047

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • abnormal locomotor behavior / IMPC
  • hyperactivity / IMPC
  • increased exploration in new environment / IMPC
  • increased circulating phosphate level / IMPC
  • short tibia / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal bone structure / IMPC
  • abnormal behavior / IMPC
  • impaired glucose tolerance / IMPC
  • decreased prepulse inhibition / IMPC
  • increased grip strength / IMPC
  • decreased respiratory quotient / IMPC
  • decreased thigmotaxis / IMPC
IMPC phenotypes (gene matching)
  • hyperactivity / IMPC
  • increased grip strength / IMPC
  • impaired glucose tolerance / IMPC
  • abnormal locomotor behavior / IMPC
  • decreased thigmotaxis / IMPC
  • increased circulating phosphate level / IMPC
  • decreased prepulse inhibition / IMPC
  • increased exploration in new environment / IMPC
  • abnormal behavior / IMPC
  • decreased respiratory quotient / IMPC
  • abnormal bone structure / IMPC
  • short tibia / IMPC
  • increased circulating alkaline phosphatase level / IMPC

Literature references

  • Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.;Garrett Lillian, Da Silva-Buttkus Patricia, Rathkolb Birgit, Gerlini Raffaele, Becker Lore, Sanz-Moreno Adrian, Seisenberger Claudia, Zimprich Annemarie, Aguilar-Pimentel Antonio, Amarie Oana V, Cho Yi-Li, Kraiger Markus, Spielmann Nadine, Calzada-Wack Julia, Marschall Susan, Busch Dirk, Schmitt-Weber Carsten, Wolf Eckhard, Wurst Wolfgang, Fuchs Helmut, Gailus-Durner Valerie, Hölter Sabine M, Hrabě de Angelis Martin, ;2022;Disease models & mechanisms;15;; 34964047

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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