C57BL/6NCrl-Mettl5em1(IMPC)Hmgu/Ieg

Status

Available to order

EMMA IDEM:13474
International strain nameC57BL/6NCrl-Mettl5em1(IMPC)Hmgu/Ieg
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolMettl5em1(IMPC)Hmgu
Gene/Transgene symbolMettl5

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.;Ignatova Valentina V, Stolz Paul, Kaiser Steffen, Gustafsson Tobias H, Lastres Palma Rico, Sanz-Moreno Adrián, Cho Yi-Li, Amarie Oana V, Aguilar-Pimentel Antonio, Klein-Rodewald Tanja, Calzada-Wack Julia, Becker Lore, Marschall Susan, Kraiger Markus, Garrett Lillian, Seisenberger Claudia, Hölter Sabine M, Borland Kayla, Van De Logt Erik, Jansen Pascal W T C, Baltissen Marijke P, Valenta Magdalena, Vermeulen Michiel, Wurst Wolfgang, Gailus-Durner Valerie, Fuchs Helmut, Hrabe de Angelis Martin, Rando Oliver J, Kellner Stefanie M, Bultmann Sebastian, Schneider Robert, ;2020;Genes & development;34;715-729; 32217665

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • decreased hematocrit / IMPC
  • abnormal head morphology / IMPC
  • abnormal cranium morphology / IMPC
  • decreased body length / IMPC
  • persistence of hyaloid vascular system / IMPC
  • abnormal lens morphology / IMPC
  • cataract / IMPC
  • abnormal cornea morphology / IMPC
  • abnormal iris morphology / IMPC
  • abnormal retina morphology / IMPC
  • decreased anxiety-related response / IMPC
  • hyperactivity / IMPC
  • decreased locomotor activity / IMPC
  • increased hematocrit / IMPC
  • abnormal vitreous body morphology / IMPC
  • decreased vertical activity / IMPC
  • abnormal retina vasculature morphology / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • iris synechia / IMPC
  • abnormal auditory brainstem response / IMPC
  • abnormal behavior / IMPC
  • increased spleen weight / IMPC
  • decreased blood urea nitrogen level / IMPC
  • abnormal optic disk morphology / IMPC
  • increased grip strength / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • decreased thigmotaxis / IMPC
IMPC phenotypes (gene matching)
  • abnormal cornea morphology / IMPC
  • abnormal head morphology / IMPC
  • persistence of hyaloid vascular system / IMPC
  • abnormal iris morphology / IMPC
  • cataract / IMPC
  • abnormal auditory brainstem response / IMPC
  • decreased hemoglobin content / IMPC
  • decreased thigmotaxis / IMPC
  • decreased erythrocyte cell number / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • abnormal cranium morphology / IMPC
  • abnormal vitreous body morphology / IMPC
  • iris synechia / IMPC
  • hyperactivity / IMPC
  • decreased vertical activity / IMPC
  • abnormal optic disk morphology / IMPC
  • abnormal lens morphology / IMPC
  • decreased locomotor activity / IMPC
  • abnormal retina morphology / IMPC
  • decreased body length / IMPC
  • abnormal behavior / IMPC
  • increased grip strength / IMPC
  • abnormal retina vasculature morphology / IMPC
  • increased spleen weight / IMPC
  • decreased anxiety-related response / IMPC
  • increased hematocrit / IMPC
  • decreased blood urea nitrogen level / IMPC
  • decreased hematocrit / IMPC

Literature references

  • The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.;Ignatova Valentina V, Stolz Paul, Kaiser Steffen, Gustafsson Tobias H, Lastres Palma Rico, Sanz-Moreno Adrián, Cho Yi-Li, Amarie Oana V, Aguilar-Pimentel Antonio, Klein-Rodewald Tanja, Calzada-Wack Julia, Becker Lore, Marschall Susan, Kraiger Markus, Garrett Lillian, Seisenberger Claudia, Hölter Sabine M, Borland Kayla, Van De Logt Erik, Jansen Pascal W T C, Baltissen Marijke P, Valenta Magdalena, Vermeulen Michiel, Wurst Wolfgang, Gailus-Durner Valerie, Fuchs Helmut, Hrabe de Angelis Martin, Rando Oliver J, Kellner Stefanie M, Bultmann Sebastian, Schneider Robert, ;2020;Genes & development;34;715-729; 32217665

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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