C57BL/6N-Jmjd6tm1c(EUCOMM)Wtsi/IegBiat

Status

Available to order

EMMA IDEM:13459
International strain nameC57BL/6N-Jmjd6tm1c(EUCOMM)Wtsi/IegBiat
Alternative nameC57BL/6N-Jmjd6tm1c(EUCOMM)Wtsi/IegBiat
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolJmjd6tm1c(EUCOMM)Wtsi
Gene/Transgene symbolJmjd6

Information from provider

ProviderMaik Dahlhoff
Provider affiliationDepartment of Biomedical Sciences, University of Veterinary Medicine
Genetic informationThis line originates from EMMA strain EM:04584, C57BL/6N-Jmjd6tm1a(EUCOMM)Wtsi/Ieg (EUCOMM ES clone EPD0158_3_A11), after breeding with a flp recombinase-deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the relevant page at the IMPC portal (https://www.mousephenotype.org/data/genes/MGI:1858910#order).
Phenotypic informationHomozygous:
No homozygous mice have been produced

Heterozygous:
No data available, no phenotype expected
Breeding history1 backcross generation to C57BL/6N after flp-deleter breeding.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal motor coordination/balance / IMPC
  • decreased mean platelet volume / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal retina vasculature morphology / IMPC
  • increased total body fat amount / IMPC
  • abnormal lens morphology / IMPC
  • abnormal retina morphology / IMPC
  • increased startle reflex / IMPC
  • abnormal retina blood vessel morphology / IMPC
  • increased NK cell number / IMPC
MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • abnormal erythropoiesis / MGI
  • double outlet right ventricle / MGI
  • abnormal intestine morphology / MGI
  • abnormal pulmonary artery morphology / MGI
  • abnormal kidney development / MGI
  • liver hypoplasia / MGI
  • abnormal thymus development / MGI
  • small thymus / MGI
  • abnormal brain development / MGI
  • exencephaly / MGI
  • abnormal lung development / MGI
  • anophthalmia / MGI
  • cyanosis / MGI
  • abnormal apoptosis / MGI
  • skin edema / MGI
  • impaired macrophage phagocytosis / MGI
  • thymus hypoplasia / MGI
  • respiratory failure / MGI
  • abnormal respiratory system morphology / MGI
  • decreased hemoglobin content / MGI
  • no phenotypic analysis / MGI
  • pallor / MGI
  • impaired macrophage chemotaxis / MGI
  • thin myocardium compact layer / MGI
  • decreased fetal size / MGI
  • fetal growth retardation / MGI
  • abnormal heart ventricle morphology / MGI
  • cellular phenotype / MGI
  • increased nucleated erythrocyte cell number / MGI
  • abnormal blood homeostasis / MGI
  • cleft secondary palate / MGI
  • ventricular septal defect / MGI
  • myocardial trabeculae hypoplasia / MGI
  • abnormal macrophage activation involved in immune response / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • abnormal head shape / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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