- abnormal motor coordination/balance / IMPC
- decreased mean platelet volume / IMPC
- preweaning lethality, complete penetrance / IMPC
- abnormal retina vasculature morphology / IMPC
- increased total body fat amount / IMPC
- abnormal lens morphology / IMPC
- abnormal retina morphology / IMPC
- increased startle reflex / IMPC
- abnormal retina blood vessel morphology / IMPC
- increased NK cell number / IMPC
C57BL/6N-Jmjd6tm1c(EUCOMM)Wtsi/IegBiat
Status | Available to order |
EMMA ID | EM:13459 |
International strain name | C57BL/6N-Jmjd6tm1c(EUCOMM)Wtsi/IegBiat |
Alternative name | C57BL/6N-Jmjd6tm1c(EUCOMM)Wtsi/IegBiat |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Jmjd6tm1c(EUCOMM)Wtsi |
Gene/Transgene symbol | Jmjd6 |
Information from provider
Provider | Maik Dahlhoff |
Provider affiliation | Department of Biomedical Sciences, University of Veterinary Medicine |
Genetic information | This line originates from EMMA strain EM:04584, C57BL/6N-Jmjd6tm1a(EUCOMM)Wtsi/Ieg (EUCOMM ES clone EPD0158_3_A11), after breeding with a flp recombinase-deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the relevant page at the IMPC portal (https://www.mousephenotype.org/data/genes/MGI:1858910#order). |
Phenotypic information | Homozygous:No homozygous mice have been producedHeterozygous:No data available, no phenotype expected |
Breeding history | 1 backcross generation to C57BL/6N after flp-deleter breeding. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | not known |
Immunocompromised | no |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- decreased hematocrit / MGI
- abnormal erythropoiesis / MGI
- double outlet right ventricle / MGI
- abnormal intestine morphology / MGI
- abnormal pulmonary artery morphology / MGI
- abnormal kidney development / MGI
- liver hypoplasia / MGI
- abnormal thymus development / MGI
- small thymus / MGI
- abnormal brain development / MGI
- exencephaly / MGI
- abnormal lung development / MGI
- anophthalmia / MGI
- cyanosis / MGI
- abnormal apoptosis / MGI
- skin edema / MGI
- impaired macrophage phagocytosis / MGI
- thymus hypoplasia / MGI
- respiratory failure / MGI
- abnormal respiratory system morphology / MGI
- decreased hemoglobin content / MGI
- no phenotypic analysis / MGI
- pallor / MGI
- impaired macrophage chemotaxis / MGI
- thin myocardium compact layer / MGI
- decreased fetal size / MGI
- fetal growth retardation / MGI
- abnormal heart ventricle morphology / MGI
- cellular phenotype / MGI
- increased nucleated erythrocyte cell number / MGI
- abnormal blood homeostasis / MGI
- cleft secondary palate / MGI
- ventricular septal defect / MGI
- myocardial trabeculae hypoplasia / MGI
- abnormal macrophage activation involved in immune response / MGI
- neonatal lethality, complete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- abnormal head shape / MGI
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