IMPC phenotypes (allele matching)
C57BL/6NTac-Park7em1(IMPC)H/H
| Status | Available to order |
| EMMA ID | EM:13335 |
| International strain name | C57BL/6NTac-Park7em1(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Park7em1(IMPC)H |
| Gene/Transgene symbol | Park7 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Young-onset Parkinson disease / Orphanet_2828
MGI phenotypes (gene matching)
- weight loss / MGI
- abnormal stationary movement / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- short stride length / MGI
- abnormal motor coordination/balance / MGI
- impaired limb coordination / MGI
- absent long term depression / MGI
- abnormal dopamine level / MGI
- increased dopamine level / MGI
- abnormal motor capabilities/coordination/movement / MGI
- decreased vertical activity / MGI
- abnormal motor learning / MGI
- neuron degeneration / MGI
- loss of dopaminergic neurons / MGI
- abnormal locomotor activation / MGI
- abnormal neurotransmitter uptake / MGI
- nervous system phenotype / MGI
- abnormal locus ceruleus morphology / MGI
- abnormal striatum morphology / MGI
- bradykinesia / MGI
- behavior/neurological phenotype / MGI
- abnormal action potential / MGI
- abnormal physiological response to xenobiotic / MGI
- abnormal behavioral response to xenobiotic / MGI
- decreased grip strength / MGI
- abnormal cellular respiration / MGI
- abnormal tricarboxylic acid cycle / MGI
- increased susceptibility to dopaminergic neuron neurotoxicity / MGI
- abnormal substantia nigra pars compacta morphology / MGI