C57BL/6NTac-Cd4em1(IMPC)H/H

Status

Available to order

EMMA IDEM:13295
International strain nameC57BL/6NTac-Cd4em1(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolCd4em1(IMPC)H
Gene/Transgene symbolCd4

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMammalian Genetics Unit, Mary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal spleen morphology / MGI
  • demyelination / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • brain inflammation / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal lymph node T cell domain morphology / MGI
  • abnormal double-positive T cell morphology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • decreased immunoglobulin level / MGI
  • abnormal immune system organ morphology / MGI
  • no phenotypic analysis / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • abnormal T cell subpopulation ratio / MGI
  • abnormal bile salt level / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • abnormal CD8-positive, alpha beta T cell morphology / MGI
  • decreased T cell number / MGI
  • increased susceptibility to parasitic infection / MGI
  • increased double-positive T cell number / MGI
  • decreased double-positive T cell number / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • absent plasma cells / MGI
  • impaired humoral immune response / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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