C57BL/6NTac-Cd4^em1(IMPC)H/H

Status	Available to order
EMMA ID	EM:13295
Citation information	RRID:IMSR_EM:13295 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Cd4^em1(IMPC)H/H
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Cd4^em1(IMPC)H
Gene/Transgene symbol	Cd4

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (gene matching)

abnormal spleen morphology / MGI
demyelination / MGI
decreased IgG level / MGI
decreased IgM level / MGI
brain inflammation / MGI
abnormal T cell differentiation / MGI
no abnormal phenotype detected / MGI
abnormal lymph node T cell domain morphology / MGI
abnormal double-positive T cell morphology / MGI
increased susceptibility to viral infection / MGI
abnormal CD4-positive, alpha beta T cell morphology / MGI
decreased immunoglobulin level / MGI
abnormal immune system organ morphology / MGI
no phenotypic analysis / MGI
absent CD4-positive, alpha beta T cells / MGI
abnormal T cell subpopulation ratio / MGI
abnormal bile salt level / MGI
decreased susceptibility to autoimmune diabetes / MGI
abnormal CD8-positive, alpha beta T cell morphology / MGI
decreased T cell number / MGI
increased susceptibility to parasitic infection / MGI
increased double-positive T cell number / MGI
decreased double-positive T cell number / MGI
decreased T cell proliferation / MGI
immune system phenotype / MGI
abnormal CD4-positive, alpha-beta T cell physiology / MGI
increased CD4-positive, alpha beta T cell number / MGI
decreased CD4-positive, alpha beta T cell number / MGI
increased CD8-positive, alpha-beta T cell number / MGI
absent plasma cells / MGI
impaired humoral immune response / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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