C57BL/6NTac-Gria2em1(IMPC)H/H

Status

Available to order

EMMA IDEM:13293
International strain nameC57BL/6NTac-Gria2em1(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolGria2em1(IMPC)H
Gene/Transgene symbolGria2

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased circulating alanine transaminase level / IMPC
  • decreased grip strength / IMPC
  • prolonged QRS complex duration / IMPC
  • preweaning lethality, complete penetrance / IMPC
IMPC phenotypes (gene matching)
  • prolonged QRS complex duration / IMPC
  • increased circulating alanine transaminase level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased grip strength / IMPC
MGI phenotypes (gene matching)
  • hippocampal neuron degeneration / MGI
  • abnormal spinal cord morphology / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • hyperactivity / MGI
  • jumpy / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • decreased exploration in new environment / MGI
  • abnormal grooming behavior / MGI
  • decreased grooming behavior / MGI
  • postnatal growth retardation / MGI
  • absent long term depression / MGI
  • impaired synaptic plasticity / MGI
  • abnormal reflex / MGI
  • abnormal touch/ nociception / MGI
  • seizures / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • premature death / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal emotion/affect behavior / MGI
  • abnormal nociception after inflammation / MGI
  • abnormal AMPA-mediated synaptic currents / MGI
  • abnormal excitatory postsynaptic potential / MGI
  • enhanced long term potentiation / MGI
  • no phenotypic analysis / MGI
  • abnormal response to novel object / MGI
  • nervous system phenotype / MGI
  • tonic-clonic seizures / MGI
  • abnormal limb posture / MGI
  • lethargy / MGI
  • hearing/vestibular/ear phenotype / MGI
  • hyperalgesia / MGI
  • abnormal cell physiology / MGI
  • increased susceptibility to neuronal excitotoxicity / MGI
  • abnormal hippocampus CA3 region morphology / MGI
  • decreased chemical nociceptive threshold / MGI
  • paraparesis / MGI
  • decreased grip strength / MGI
  • enhanced AMPA-mediated synaptic currents / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • abnormal circadian sleep/wake cycle / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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