IMPC phenotypes (gene matching)
B6;Cg-Pmeltm1.1(cre/ERT2)Jkn/H
| Status | Available to order |
| EMMA ID | EM:13225 |
| Citation information | RRID:IMSR_EM:13225 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;Cg-Pmeltm1.1(cre/ERT2)Jkn/H |
| Alternative name | Pmel-CMN |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Pmeltm1.1(cre/ERT2)Jkn |
| Gene/Transgene symbol | Pmel |
Information from provider
| Provider | Richard Mort |
| Provider affiliation | Biomedical and Life Sciences, Lancaster University |
| Additional owner | Frank Constantini's group developed the R26YFPR allele but widely available. |
| Genetic information | Pmel-CMN mice carry a knock-in cassette replacing the STOP codon of the Pmel gene with creERT2-2a-marcks-mKate-2a-H2BCerulean. |
| Phenotypic information | Homozygous:No phenotype.Heterozygous:No phenotype. |
| Breeding history | Pmel-CMN generated in E14 129P2/OlaHsd ES cells. Outcrossed to C57BL/6. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- diluted coat color / MGI
- irregular coat pigmentation / MGI
- pigmentation phenotype / MGI
- no phenotypic analysis / MGI
- abnormal melanosome morphology / MGI
- homeostasis/metabolism phenotype / MGI
- hematopoietic system phenotype / MGI
- reduced hair shaft melanin granule number / MGI
- abnormal tail hair pigmentation / MGI
- abnormal retinal melanin granule morphology / MGI
- abnormal choroid melanin granule morphology / MGI
Literature references
- Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2-mediated recombination in the melanocyte lineage.;Wilkinson Emma L, Brennan Louise C, Harrison Olivia J, Crane-Smith Zoe, Gautier Philippe, Keighren Margaret A, Budd Peter, Swaminathan Karthic, Machesky Laura M, Allinson Sarah L, Jackson Ian J, Mort Richard L, ;2023;Pigment cell & melanoma research;36;71-77; 36412082