B6;Cg-Pmeltm1.1(cre/ERT2)Jkn/H
| Status | Available to order |
| EMMA ID | EM:13225 |
| International strain name | B6;Cg-Pmeltm1.1(cre/ERT2)Jkn/H |
| Alternative name | Pmel-CMN |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Pmeltm1.1(cre/ERT2)Jkn |
| Gene/Transgene symbol | Pmel |
Information from provider
| Provider | Richard Mort |
| Provider affiliation | Biomedical and Life Sciences, Lancaster University |
| Additional owner | Frank Constantini's group developed the R26YFPR allele but widely available. |
| Genetic information | Pmel-CMN mice carry a knock-in cassette replacing the STOP codon of the Pmel gene with creERT2-2a-marcks-mKate-2a-H2BCerulean. |
| Phenotypic information | Homozygous:No phenotype.Heterozygous:No phenotype. |
| Breeding history | Pmel-CMN generated in E14 129P2/OlaHsd ES cells. Outcrossed to C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2-mediated recombination in the melanocyte lineage.;Wilkinson Emma L, Brennan Louise C, Harrison Olivia J, Crane-Smith Zoe, Gautier Philippe, Keighren Margaret A, Budd Peter, Swaminathan Karthic, Machesky Laura M, Allinson Sarah L, Jackson Ian J, Mort Richard L, ;2023;Pigment cell & melanoma research;36;71-77; 36412082