C57BL/6N-Atm1Brd Dnmt3atm1c(KOMP)Wtsi/WtsiOrl

Status

Available to order

EMMA IDEM:13219
International strain nameC57BL/6N-Atm1Brd Dnmt3atm1c(KOMP)Wtsi/WtsiOrl
Alternative nameC57BL/6N-A tm1Brd Dnmt3c tm1a(KOMP)Wtsi/WtsiOrl
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolDnmt3atm1c(KOMP)Wtsi
Gene/Transgene symbolDnmt3a

Information from provider

ProviderCécile FREMOND
Provider affiliationCNRS-TAAM
Genetic informationThis mouse line originates from KOMP ES clone EPD0332_1_C06. For further details on the construction of this clone see the page at the IMPC portal. The tm1a mice have been crossed with flp recombinase-expressing mice (EM:05490, C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics) to obtain the tm1c allele.
Phenotypic informationHomozygous:
Homozygous mice have not been generated

Heterozygous:
Null
Breeding historyRederived tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6N Tac

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal bone structure / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased grip strength / IMPC
  • decreased lean body mass / IMPC
  • decreased circulating glucose level / IMPC
  • decreased exploration in new environment / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • increased total body fat amount / IMPC
  • convulsive seizures / IMPC
  • abnormal embryo size / IMPC
MGI phenotypes (gene matching)
  • decreased body size / MGI
  • postnatal growth retardation / MGI
  • premature death / MGI
  • postnatal lethality, complete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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