- abnormal bone structure / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- decreased circulating cholesterol level / IMPC
- increased grip strength / IMPC
- decreased lean body mass / IMPC
- decreased circulating glucose level / IMPC
- decreased exploration in new environment / IMPC
- decreased circulating HDL cholesterol level / IMPC
- increased total body fat amount / IMPC
- convulsive seizures / IMPC
- abnormal embryo size / IMPC
C57BL/6N-Atm1Brd Dnmt3atm1c(KOMP)Wtsi/WtsiOrl
Status | Available to order |
EMMA ID | EM:13219 |
Citation information | RRID:IMSR_EM:13219 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6N-Atm1Brd Dnmt3atm1c(KOMP)Wtsi/WtsiOrl |
Alternative name | C57BL/6N-A tm1Brd Dnmt3c tm1a(KOMP)Wtsi/WtsiOrl |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Dnmt3atm1c(KOMP)Wtsi |
Gene/Transgene symbol | Dnmt3a |
Information from provider
Provider | Cécile FREMOND |
Provider affiliation | CNRS-TAAM |
Genetic information | This mouse line originates from KOMP ES clone EPD0332_1_C06. For further details on the construction of this clone see the page at the IMPC portal. The tm1a mice have been crossed with flp recombinase-expressing mice (EM:05490, C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics) to obtain the tm1c allele. |
Phenotypic information | Homozygous:Homozygous mice have not been generatedHeterozygous:Null |
Breeding history | Rederived tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6NTac males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Sporadic pheochromocytoma/secreting paraganglioma / Orphanet_276621
- Tatton-Brown-Rahman syndrome / Orphanet_404443
IMPC phenotypes (gene matching)
Information on how we integrate external resources can be found here
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