- abnormal bone structure / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- decreased circulating cholesterol level / IMPC
- increased grip strength / IMPC
- decreased lean body mass / IMPC
- decreased circulating glucose level / IMPC
- decreased exploration in new environment / IMPC
- decreased circulating HDL cholesterol level / IMPC
- increased total body fat amount / IMPC
- convulsive seizures / IMPC
- abnormal embryo size / IMPC
C57BL/6N-Atm1Brd Dnmt3atm1c(KOMP)Wtsi/WtsiOrl
Status | Available to order |
EMMA ID | EM:13219 |
International strain name | C57BL/6N-Atm1Brd Dnmt3atm1c(KOMP)Wtsi/WtsiOrl |
Alternative name | C57BL/6N-A tm1Brd Dnmt3c tm1a(KOMP)Wtsi/WtsiOrl |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Dnmt3atm1c(KOMP)Wtsi |
Gene/Transgene symbol | Dnmt3a |
Information from provider
Provider | Cécile FREMOND |
Provider affiliation | CNRS-TAAM |
Genetic information | This mouse line originates from KOMP ES clone EPD0332_1_C06. For further details on the construction of this clone see the page at the IMPC portal. The tm1a mice have been crossed with flp recombinase-expressing mice (EM:05490, C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics) to obtain the tm1c allele. |
Phenotypic information | Homozygous:Homozygous mice have not been generatedHeterozygous:Null |
Breeding history | Rederived tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6N Tac |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Sporadic pheochromocytoma/secreting paraganglioma / Orphanet_276621
- Tatton-Brown-Rahman syndrome / Orphanet_404443
IMPC phenotypes (gene matching)
Information on how we integrate external resources can be found here
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