IMPC phenotypes (gene matching)
C57BL/6NTac-Btktm1c(EUCOMM)Hmgu/IcsOrl
| Status | Available to order |
| EMMA ID | EM:13217 |
| Citation information | RRID:IMSR_EM:13217 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Btktm1c(EUCOMM)Hmgu/IcsOrl |
| Alternative name | C57BL/6NTac-Btk tm1c(EUCOMM)Hmgu/IcsOrl |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Btktm1c(EUCOMM)Hmgu |
| Gene/Transgene symbol | Btk |
Information from provider
| Provider | Cécile FREMOND |
| Provider affiliation | CNRS-TAAM-UAR44 |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0522_1_A11. For further details on the construction of this clone see the page at the IMPC portal. The tm1a mice have been crossed with flp recombinase-expressing mice (EM:05490, C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics) to obtain the tm1c allele. |
| Phenotypic information | Homozygous:Homozygous mice have not been generatedHeterozygous:Null |
| Breeding history | Rederived tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6NTac males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia / Orphanet_632
- X-linked agammaglobulinemia / Orphanet_47
MGI phenotypes (gene matching)
- abnormal bone marrow cell number / MGI
- decreased neutrophil cell number / MGI
- spleen hypoplasia / MGI
- impaired myelopoiesis / MGI
- decreased IgM level / MGI
- autoimmune response / MGI
- abnormal B cell differentiation / MGI
- abnormal lymphopoiesis / MGI
- abnormal pre-B cell morphology / MGI
- abnormal macrophage physiology / MGI
- abnormal B cell physiology / MGI
- abnormal neutrophil physiology / MGI
- impaired neutrophil phagocytosis / MGI
- decreased IgD level / MGI
- increased IgG level / MGI
- increased IgM level / MGI
- increased IgE level / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased B cell number / MGI
- decreased acute inflammation / MGI
- decreased B cell proliferation / MGI
- abnormal B cell proliferation / MGI
- immune system phenotype / MGI
- decreased follicular B cell number / MGI
- increased pro-B cell number / MGI
- decreased transitional stage B cell number / MGI
- absent B-1a cells / MGI
- decreased mature B cell number / MGI
- increased immature B cell number / MGI
- abnormal B cell activation / MGI
- abnormal leukocyte morphology / MGI
- decreased spleen germinal center number / MGI
- decreased spleen germinal center size / MGI
- decreased IgG3 level / MGI
- abnormal lymph node germinal center morphology / MGI
- increased susceptibility to induced colitis / MGI
- decreased splenocyte number / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI